Results 141 to 150 of about 2,316 (194)

Studies on the antidiuretic action of aminopyrine

Metabolism, 1964
Abstract Changes in urine flow, urine osmolality, and endogenous creatinine clearance were measured after the administration of aminopyrine to water-loaded, anesthetized dogs. A minimum dose of 200 mg./Kg. of aminopyrine was required to produce an antidiuresis with production of a hypertonic urine, when given intravenously. A dose of 2.5 mg./Kg. into
L, STROM, L, ZEMEK
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Metabolism and excretion of aminopyrine by cows

Toxicology and Applied Pharmacology, 1967
Abstract The metabolism and excretion of aminopyrine were studied in normal lactating dairy cattle. Cows were placed in a stall and catheters for blood and urine collection were fixed in place. Loading doses of aminopyrine ranging from 11.3 to 35.3 mg/kg were given intravenously. Plasma, milk, and urine samples were taken simultaneously for 24 hours.
N C, Banerjee, G E, Miller, C M, Stowe
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Interaction between antipyrine and aminopyrine

Clinical Pharmacology & Therapeutics, 1976
Aminopyrine administered to normal human volunteers in an oral dose of either 9 mg/kg or 4.5 mg/kg prolonged the plasma half‐life and reduced the metabolic clearance rate of antipyrine (18 mg/kg, orally) without changing its apparent volume of distribution.
E S, Vesell, G T, Passananti, G W, Hepner   +2 more
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Oxidation of Aminopyrine by Hypochlorite to a Reactive Dication: Possible Implications for Aminopyrine-Induced Agranulocytosis

Chemical Research in Toxicology, 1995
Aminopyrine is associated with a high incidence of agranulocytosis. It is known to be oxidized by peroxidases and hypochlorous acid to a blue cation radical. It has been proposed that the mechanism by which hypochlorous acid oxidizes aminopyrine to a cation radical involves N-chlorination followed by loss of a chlorine radical.
J P, Uetrecht, H M, Ma, E, MacKnight, R, McClelland   +3 more
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The mechanism of aminopyrine convulsions

Bulletin of Experimental Biology and Medicine, 1959
When injected into the common carotid artery the convulsive dose of aminopyrine in dogs was 2.5 mg/kg, while into the femoral artery or vein it was about 30 mg/kg. After unilateral ligation of the internal carotid artery the convulsive dose of aminopyrine injected into the ipsilateral common carotid artery increased greatly and even exceeded the ...
B. M. Brin, R. D. Khubetsova, N. V. Streshneva   +2 more
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The Toxicity of Aminopyrine

JAMA, 1961
To the Editor:— I must take issue with certain statements in an article ( JAMA 176 :1112 [July 1] 1961) which describes the successful treatment of a case of diabetes insipidus with aminopyrine. The writers recommend such therapy and state that the potential hematologic hazard in the use of aminopyrine "has been greatly overemphasized." As evidence ...
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Aminopyrine in Hodgkin's Disease

JAMA, 1963
To the Editor: —Dr. Trimble's somewhat acidulous remarks concerning the hazards of aminopyrine serve only to call attention to the inconsistencies of our profession. I am sure that Dr. Trimble's own staff uses butazolidin, corticosteroids, apresoline, and many other drugs of current vintage whose effects are purely symptomatic but which, nevertheless,
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THE STRUCTURE OF AMINOPYRINE SALTS

Canadian Journal of Chemistry, 1965
The infrared spectra of aminopyrine salts can be interpreted on the basis of protonation of the 4-dimethylamino group nitrogen atom. In the hydrohalides the normal [Formula: see text] hydrogen bond occurs, but in salts with complex anions an intramolecular [Formula: see text] hydrogen bond is probable, though an intermolecular one between the same ...
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NO AMINOPYRINE IN "ANALGIA" AND "ANTABS"

Journal of the American Medical Association, 1938
To the Editor:— In Dr. Kracke's paper on the relation of drug therapy to neutropenic states inThe Journal, October 1, he includes on page 1259 a list of preparations described as containing aminopyrine. In this list appear the names of two of our products, namely "Analgia" and "Antabs," neither of which contains aminopyrine. The product marketed under
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Depression of Aminopyrine Metabolism by Influenza Vaccination

New England Journal of Medicine, 1981
HEPATIC cytochrome P-450 is important in the metabolism of many drugs.1 Multiple factors, such as ingestion of inducing agents (e.g., phenobarbital), nutritional state, and the presence of liver disease, influence hepatic levels of cytochrome P-450. Recent studies have demonstrated that immunologic stimulation by administration of bacillus Calmette ...
P, Kramer, C J, McClain
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