Results 51 to 60 of about 5,991,558 (223)

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas   +6 more
wiley   +1 more source

What is the optimal timing to assess the effect of 5-ASA in patients with mild-to-moderate ulcerative colitis? A single-center prospective observational study

European Journal of Medical Research
Background First-line therapy for mild-to-moderate ulcerative colitis is 5-aminosalicylic acid. Optimal timing for the first evaluation after initiation remains unclear.
Yu Da, Fang Wang, Jiaqi Zhang, Tiantian Zhang, Xiaoning Liu, Jindan He, Yanting Shi, Tong Wu, Jie Liang   +8 more
doaj   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model

PLoS ONE, 2017
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms ...
Sónia R. Pereira, R. Pereira, Isabella F S Figueiredo, V. Freitas, T. Dinis, L. Almeida   +5 more
semanticscholar   +1 more source

Sulfasalazine Enhances Copper Toxicity in Danio rerio Larvae: Divergent Protective Roles of Deferoxamine and Ferrostatin‐1

Environmental Toxicology, EarlyView.
ABSTRACT Copper is an environmental contaminant capable of disrupting redox homeostasis and impairing antioxidant defenses in aquatic organisms, thereby increasing susceptibility to oxidative stress. The cystine/glutamate antiporter (system xc−) plays a central role in maintaining intracellular glutathione (GSH) levels, a major antioxidant defense ...
Maria Vitória Takemura Mariano, Pedro Henrique Vicenzi, Vitor Oliveira de Rosso, Mauro Eugênio Medina Nunes, Layla da Silva Braga, Analía Del Valle Garnero, Ricardo José Gunski, Marcelo Farina, Thaís Posser, Jeferson Luis Franco   +9 more
wiley   +1 more source

Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment

Journal of Microbiology, Immunology and Infection, 2018
Background: Multidrug-resistant and extensively drug-resistant tuberculosis infections cause public health concerns worldwide. Local epidemiologic data about the drug resistance of Mycobacterium tuberculosis isolate (Mtb) is critical to guide appropriate
Cheng-Yu Kuo, Wen-Hung Wang, Chung-Hao Huang, Yen-Hsu Chen, Po-Liang Lu   +4 more
doaj   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized controlled trial

Bioscience Reports, 2018
We conducted a meta-analysis to evaluate the effect of probiotic combined with aminosalicylic on induction remission maintenance treatment of ulcerative colitis (UC).
Lijun Peng, Yan Zhong, Aiping Wang, Zhisheng Jiang   +3 more
semanticscholar   +1 more source

Impact of Zinc‐Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Zinc (Zn) deficiency occurs in 40% of patients with ulcerative colitis (UC). Although Zn‐dependent enzymes are involved in intestinal immune regulation, their relationships with Zn deficiency and mucosal inflammation remain unclear.
Yuki Murakami, Taiho Kambe, Yu Kobayashi, Aki Sakatani, Katsuyoshi Ando, Nobuhiro Ueno, Kentaro Moriichi, Mikihiro Fujiya   +7 more
wiley   +1 more source