Results 41 to 50 of about 5,991,558 (223)
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source
Renal Effects of Long-Term Treatment with 5-Aminosalicylic Acid
Canadian Journal of Gastroenterology, 2009 BACKGROUND: A number of case reports link the use of 5-aminosalicylic acid (5-ASA) to interstitial nephritis in patients with inflammatory bowel disease (IBD).
Harshna Patel +2 more
doaj +1 more source
Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis
Scientific Reports, 2019 Thymidylate synthase A (ThyA) is the key enzyme involved in the folate pathway in Mycobacterium tuberculosis. Mutation of key residues of ThyA enzyme which are involved in interaction with substrate 2′-deoxyuridine-5′-monophosphate (dUMP), cofactor 5,10 ...
B. Pandey +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye +9 more
wiley +1 more source
Carboxylation of hydroxyarens with metal alkyl carbonates
Green Processing and Synthesis, 2015 The objective of this work was to investigate the possibility of using alkali metal salts of ethylcarbonic acid as a carboxylating reagent in phenol (naphthols) carboxylation and developing a new and simple method for the synthesis of hydroxybenzoic and ...
Suerbaev Khakim A. +2 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Aim Stoma creation is often required in Crohn's disease (CD), most commonly because of progressive anorectal disease. As stoma closure strongly influences long‐term quality of life and surgical decision‐making, this study evaluated the indications and long‐term outcomes of stoma creation in patients with CD.
Kentaro Nagano +9 more
wiley +1 more source
2-Hydroxy-5-{[(E)-4-methoxybenzylidene]azaniumyl}benzoate
Acta Crystallographica Section E, 2010 In the title zwitterion, C15H13NO4, obtained from the condensation of 5-aminosalicylic acid and 4-methoxybenzaldehyde, the 4-hydoxyanilinic group of the 5-aminosalicylic acid moiety and the 4-methoxybenzaldehyde moiety are twisted with respect to one ...
Shahbaz Ahmad +3 more
doaj +1 more source
Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn's disease.
Cochrane Database of Systematic Reviews, 2019 BACKGROUND Crohn's disease (CD) is a chronic inflammatory disorder that can involve any part of the gastrointestinal tract. 5-Aminosalicylates (5-ASAs) are locally acting, anti-inflammatory compounds that reduce inflammation of the colonic mucosa with ...
Teuta Gjuladin-Hellon +3 more
semanticscholar +1 more source
Food Safety and Health, EarlyView.In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso +3 more
wiley +1 more source
Intestinal Research, 2017 Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with ...
Jina Yeo +8 more
doaj +1 more source