Results 21 to 30 of about 38,104 (229)
Acute Hepatotoxicity of Intravenous Amiodarone: Case Report and Review of the Literature
, 2017 Amiodarone is a class III antiarrhythmic drug widely used for the treatment of both supraventricular and ventricular arrhythmias in intensive care unit. Hepatotoxicity of amiodarone is usually mild and delayed onset.
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio +11 more
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Voltage-Dependent Effects of Amiodarone on D540K HERG Channels
, 2003 2003-12To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage-dependent block by amiodarone, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes.
Kamiya, Kaichiro +4 more
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Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes
, 2003 2003-12Amiodarone is a potent antiarrhythmic agent in the treatment of the atrial fibrillation and flutter. However, underlying electrophysiological mechanism are not clarified yet. In the present study, we investigated the acute effects of amiodarone on
Kamiya, Kaichiro, Lu, Zhibo
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British Journal of Clinical Pharmacology, EarlyView.Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel +4 more
wiley +1 more source
, 2009 Aims ATI-2042 (budiodarone) is a chemical analogue of amiodarone with a half life of 7 h. It is electrophysiologically similar to amiodarone, but may not have metabolic and interaction side effects.
Camm, AJ +5 more
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Acta Dermato-Venereologica, 1987 Four patients with photoreactions after Amiodarone therapy are described. The action spectrum for photosensitivity was found in the UVA region. Pigmentation seems to be due to wavelengths below 360 nm.
G, Roupe, O, Larkö, S B, Olsson
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The Effects of Amiodarone on the Thyroid* [PDF]
Endocrine Reviews, 2001 Amiodarone is a benzofuranic-derivative iodine-rich drug widely used for the treatment of tachyarrhythmias and, to a lesser extent, of ischemic heart disease. It often causes changes in thyroid function tests (typically an increase in serum T(4) and rT(3), and a decrease in serum T(3), concentrations), mainly related to the inhibition of 5'-deiodinase ...
MARTINO, ENIO +3 more
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British Journal of Clinical Pharmacology, EarlyView.Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
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British Journal of Clinical Pharmacology, EarlyView.Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval +6 more
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