Drooling as a Red Flag: Insights From a Case Series in Severe Dermatomyositis With Literature Review
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Dermatomyositis (DM) is a rare idiopathic inflammatory disease characterized by progressive proximal muscle weakness and distinctive dermatologic manifestations. Although dysphagia is a recognized complication of oropharyngeal muscle involvement, drooling (sialorrhea) is infrequently described and may be a marker of severe disease.
Alireza Mirzamohamadi +9 more
wiley +1 more source
Family health history and pharmacogenomics show cross generation premature amitriptyline discontinuation is associated with CYP2C19 loss of-function enrichment. [PDF]
Commun Med (Lond)Magavern EF +4 more
europepmc +1 more source
Annals of the Child Neurology Society, Volume 3, Issue 4, Page 314-323, December 2025.ABSTRACT Background Pathogenic CYFIP2 variants cause developmental and epileptic encephalopathy (DEE), characterized by early‐onset intractable epilepsy and developmental delay. The disease course has not been delineated. Codon Arg87 is a de novo mutational hotspot associated with a severe DEE phenotype via gain‐of‐function mechanisms. Currently, there
Michaela Squire +3 more
wiley +1 more source
Pharmacological Insights into Optimal Dosing in Burning Mouth Syndrome: A Narrative Review of the Non-Linear Actions of Amitriptyline and Aripiprazole. [PDF]
J Clin MedNagamine T.
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Saliva as a TDM Matrix and Its Application in the Model‐Informed Precision Dosing
The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1650-1660, December 2025.Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu +9 more
wiley +1 more source
Lipid emulsion in blood increases extraction of amitriptyline in liposome augmented peritoneal dialysis in rats chronically dosed with amitriptyline: could nanoparticles mitigate the limitations to dialysis in intoxication? [PDF]
Intensive Care Med ExpKoh J +4 more
europepmc +1 more source
Laryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.ABSTRACT Objective In adult patients who undergo soft tissue and maxillomandibular advancement (MMA) sleep surgery for obstructive sleep apnea (OSA), we identify preoperative pain diagnoses and postoperative pain medication dispensing patterns by surgery type.
Ghedak Ansari +4 more
wiley +1 more source
Effect of Low-Dose Amitriptyline on Autonomic Functions and Peripheral Blood Flow in Fibromyalgia: A Pilot Study [PDF]
, 2011 Poorvi Kulshreshtha +4 more
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Obesity, Volume 33, Issue 12, Page 2246-2263, December 2025.ABSTRACT The presence of excess weight is no longer a distinguishing feature between patients with type 1 diabetes (T1D) and those with type 2 diabetes (T2D). Obesity treatment in patients with T2D improves glycemic control and reduces or even eliminates medication burden.
Kathleen R. Ruddiman +2 more
wiley +1 more source
Long‐term outcome of presumptive idiopathic hyperesthesia syndrome in a dog treated with fluoxetine
Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.Abstract A 9‐year‐old, 10 kg, male, neutered, mixed‐breed dog was evaluated for a history of daily episodes of thoracic and lumbar hair horripilation with potential hypersensitivity and discomfort for at least 1 year, as reported by the owner. Dermatological disease was ruled out.
Claudia Pauciulo, Antonella Gallucci
wiley +1 more source