Results 51 to 60 of about 219,440 (288)

Analysis of the Failure Modes in the Polymer Electrolyte Fuel Cell Cold-Start Process—Anode Dehydration or Cathode Pore Blockage

Energies, 2020
In this study, the cold-start failure processes of a polymer electrolyte fuel cell have been investigated numerically for different initial membrane water content λ 0 and the startup current densities I 0 .
Lei Yao, Fangfang Ma, Jie Peng, Jianbo Zhang, Yangjun Zhang, Jianpeng Shi   +5 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Impacts of the substrate stiffness on the anti-wear performance of graphene

AIP Advances, 2019
Owing to its excellent mechanical and tribological properties, graphene has been proposed to be a promising atomically-thin solid lubricant for engineering applications.
Quanzhou Yao, Yizhou Qi, Ji Zhang, Shuai Zhang, Pei Zhao, Hongtao Wang, Xi-Qiao Feng, Qunyang Li   +7 more
doaj   +1 more source

The Effects of Corrosive Media on Fatigue Performance of Structural Aluminum Alloys

Metals, 2016
The effects of corrosive media on rotating bending fatigue lives (the cyclic numbers from 104 to 108) of different aluminum alloys were investigated, which involved the corrosion fatigue lives of five kinds of aluminum alloys in air, at 3.5 wt. % and 5.0
Huihui Yang, Yanling Wang, Xishu Wang, Pan Pan, Dawei Jia   +4 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]

, 2018
Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Duncavage, Eric J., Griffith, Malachi, Griffith, Obi L., Hassan, Anjum, Lee, Yi-Shan, Miller, Christopher A., O\u27Laughlin, Michelle D., Schmidt, Heather, Skidmore, Zachary L., Tian, Ling, Tricarico, Christopher, Uy, Geoffrey L., Wartman, Lukas D., Welch, John S.   +13 more
core   +2 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia [PDF]

, 2016
We report the findings from a patient who presented with a concurrent mediastinal germ cell tumor (GCT) and acute myeloid leukemia (AML). Bone marrow pathology was consistent with a diagnosis of acute megakaryoblastic leukemia (AML M7), and biopsy of an ...
Demeter, Ryan T, Duncavage, Eric J, Griffith, Malachi, Griffith, Obi L, Hagemann, Ian S, Lu, Charles, Magrini, Vincent, Miller, Christopher A, O\u27Laughlin, Michelle, Ozenberger, Bradley A, Riedell, Peter, Wartman, Lukas D, Westervelt, Peter   +12 more
core   +2 more sources