Results 161 to 170 of about 192,136 (258)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Investigations of microbial adaptation to singular, binary, and fully formulated quaternary ammonium compounds. [PDF]

Appl Environ Microbiol
Willmott T, Kelly PP, Jadaan L, Gifford DR, Mercer SD, Humphreys GJ, Knight CG, Lu JR, McBain AJ.   +8 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds. [PDF]

Int J Mol Sci
Fedorowicz J, Sączewski J.
europepmc   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Erratum for Ivanova et al., "Large-scale phenotypic and genomic analysis of <i>Listeria monocytogenes</i> reveals diversity in the sensitivity to quaternary ammonium compounds but not to peracetic acid". [PDF]

Appl Environ Microbiol
Ivanova M, Laage Kragh M, Szarvas J, Tosun ES, Holmud NF, Gmeiner A, Amar C, Guldimann C, Huynh TN, Karpíšková R, Rota C, Gomez D, Aboagye E, Etter A, Centorame P, Torresi M, De Angelis ME, Pomilio F, Okholm AH, Xiao Y, Kleta S, Lüth S, Pietzka A, Kovacevic J, Pagotto F, Rychli K, Zdovc I, Papić B, Heir E, Langsrud S, Møretrø T, Brown P, Kathariou S, Stephan R, Tasara T, Dalgaard P, Njage PMK, Fagerlund A, Aarestrup F, Truelstrup Hansen L, Leekitcharoenphon P.   +40 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Large-scale phenotypic and genomic analysis of <i>Listeria monocytogenes</i> reveals diversity in the sensitivity to quaternary ammonium compounds but not to peracetic acid. [PDF]

Appl Environ Microbiol
Ivanova M, Laage Kragh M, Szarvas J, Tosun ES, Holmud NF, Gmeiner A, Amar C, Guldimann C, Huynh TN, Karpíšková R, Rota C, Gomez D, Aboagye E, Etter A, Centorame P, Torresi M, De Angelis ME, Pomilio F, Okholm AH, Xiao Y, Kleta S, Lüth S, Pietzka A, Kovacevic J, Pagotto F, Rychli K, Zdovc I, Papić B, Heir E, Langsrud S, Møretrø T, Brown P, Kathariou S, Stephan R, Tasara T, Dalgaard P, Njage PMK, Fagerlund A, Aarestrup F, Truelstrup Hansen L, Leekitcharoenphon P.   +40 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source