Results 41 to 50 of about 447,343 (334)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

The Relation Between the Quantity of Ammonium Compounds in Tobacco and the Nitrogen Monoxide (NO) Levels in the Smoke of Cigarettes Marketed in the Netherlands

Contributions to Tobacco and Nicotine Research, 2006
It has been suggested that ammonium compounds in tobacco generate nitrogen monoxide (NO) in cigarette smoke. This causes the smoke to retain the broncho-dilatory properties of the tobacco, which leads to an increased uptake of nicotine and thus to a ...
van Amsterdam JGC, Brunt TM, Verlaan APJ, Cleven RFMJ, Opperhuizen A, Vleeming W   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Methods for determining cationic surface solids (critical review)

Український журнал військової медицини
The purpose of this articule to summarize and systematize information on methods for identification and quantification of quaternary ammonium compounds. Results.
O. V. Kovalska, M. Ye. Blazheyevskіy, E. O. Tsapko   +2 more
doaj   +1 more source

Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides

Antibiotics, 2023
Eight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained.
Karol Sikora, Piotr Szweda, Karolina Słoczyńska, Justyna Samaszko-Fiertek, Janusz Madaj, Beata Liberek, Elżbieta Pękala, Barbara Dmochowska   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Struvite Crystallization for Ammonium Removal from Cow Urine with Bulkhead Reactor

Jurnal Teknik Kimia dan Lingkungan, 2021
The presence of ammonium content in cow urine waste damages the aquatic ecosystem due to its toxicity. Ammonium content can be reduced by removing it through struvite crystallization.
Luluk Edahwati, Sutiyono, Fauziah Hilda Alvira, Rizqi Rendri Anggriawan   +3 more
doaj   +1 more source

Impact of aeration on the removal of organic matter and nitrogen compounds in constructed wetlands treating the liquid fraction of piggery manure [PDF]

, 2019
The increasing demand for sustainable, robust and cost-efficient wastewater treatment techniques strengthen the implementation of constructed wetlands (CWs) in the agricultural sector.
Donoso Pantoja, Natalia Carolina, Kumar Biswas, Jayanta, Meers, Erik, Michels, Evi, van Oirschot, Dion   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source