Results 91 to 100 of about 13,912 (195)

Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]

, 2013
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth, Joseph, Deokary, Kabanywanyi, Abdunoor M, Minzi, Omary Ms, Mugittu, Kefas, Premji, Zulfiqarali   +5 more
core   +3 more sources

Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability [PDF]

, 2013
Background: The need for new malaria surveillance tools and strategies is critical, given improved global malaria control and regional elimination efforts.
Abdullah S Ali, Anders Björkman, Andreas Mårtensson, Berit Aydin-Schmidt, Delér Shakely, DS Ishengoma, E Kamau, G Froberg, G Holmgren, G Snounou, J Hwang, José P Gil, L Cnops, LC Okell, Louise Jörnhagen, Max Petzold, MI Veiga, Mwinyi I Msellem, N Steenkeste, Pedro E Ferreira, RN Price, S Bereczky, S Dahlstrom, SA Greenspoon, SE Shokoples, Ulrika Morris, V Veron   +26 more
core   +2 more sources

Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug sensitivity. [PDF]

, 2016
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012 ...
Brooker, SJ, Conrad, MD, Dorsey, G, Kamya, MR, Legac, J, Nankabirwa, JI, Nsobya, SL, Rosenthal, PJ, Staedke, SG, Tukwasibwe, S, Tumwebaze, P, Wandera, B   +11 more
core   +3 more sources

Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Pharmaceutical Sciences, 2016
Background: Chloroquine and amodiaquine are used in the prophylaxis and treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On the other hand, there is no promising hepatoprotective agent for prophylaxis or treatment of
Akram Jamshidzadeh, Reza Heidari, Farzaneh Abazari, Maral Ramezani, Forouzan Khodaei, Mohammad Mehdi Ommati, Maryam Ayarzadeh, Roya Firuzi, Arastoo Saeedi, Negar Azarpira, Asma Najibi
doaj   +1 more source

Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children [PDF]

, 2015
Semilog plots of deficit in haematocrit from 30 % versus time in children with haematocrit
Adejumoke I. Ayede, Akintunde Sowunmi, Bayo Fatunmbi, Elsie O. Adewoye, Godwin Ntadom, Kazeem Akano, Temitope Aderoyeje   +6 more
core   +4 more sources

Amodiaquine Modulates Aggregation and Disassembly of Amyloid-β and Tau and Attenuates Neuroinflammatory Responses and Aβ Production

Pharmaceutics
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles, which synergistically accelerate disease progression.
Sinae Jang, Sujin Kim, Na-Hyun Kim, Soo Jung Shin, Vijay Kumar, Jeong Gyu Son, Minseok Lee, Choon-gil Kim, Eun-Kyung Lim, Hyunju Chung, Young Ho Koh, Yunkwon Nam, Minho Moon   +12 more
doaj   +1 more source

Preparation and evaluation of mixed-ligand complexes of Cu (II) and Co (II) with amodiaquine hydrochloride and sulphamethazine

Journal of Applied Sciences and Environmental Management, 2018
Cu (ll) and Co (II) complexes of amodiaquine hydrochloride and sulphamethazine (AMOSUF) have been prepared and characterized by elemental analysis, molar conductivity, FTIR and electronic spectroscopy.
E.A. Enemose, E.E. Akporhonor, B Kpomah
doaj   +1 more source

Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso

Malaria Journal, 2008
Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are ...
Meissner Peter, Coulibaly Boubacar, Mockenhaupt Frank P, Mandi Germain, Müller Olaf   +4 more
doaj   +1 more source

Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo

International Journal of Infectious Diseases, 2019
Background: Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy, and safety. Individuals carrying the CYP2C8*
Simon Marie Peko, Francine Ntoumi, Christevy Vouvoungui, David Nderu, Simon Charles Kobawila, Thirumalaisamy P. Velavan, Félix Koukouikila-Koussounda   +6 more
doaj   +1 more source

Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo. [PDF]

, 2006
Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and ...
Bonnet, M, Cohuet, S, D'Alessandro, U, Guthmann, J P, Van Herp, M, Van Overmeir, C   +5 more
core   +2 more sources