Results 91 to 100 of about 17,783 (291)

Concentration–Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double‐Blind, Placebo‐Controlled Study in Healthy Adults of African Sub‐Saharan Origin

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT A novel oral combination of the long‐acting antimalarials pyronaridine (PYR) and piperaquine (PQP) has potential for malaria chemoprevention. This single‐center randomized, double‐blind, placebo‐controlled study assessed the effects of PYR and PQP alone and when co‐administered on Fridericia‐corrected QT interval (QTcF).
Mathieu Felices, Isabelle Borghini‐Fuhrer, Nada Abla, Stephan Chalon   +3 more
wiley   +1 more source

In Vivo Activity of Amodiaquine against Ebola Virus Infection

Scientific Reports, 2019
During the Ebola virus disease (EVD) epidemic in Western Africa (2013‒2016), antimalarial treatment was administered to EVD patients due to the high coexisting malaria burden in accordance with World Health Organization guidelines.
Lisa Evans DeWald, Joshua C. Johnson, D. Gerhardt, Lisa M. Torzewski, E. Postnikova, A. Honko, Krisztina B. Janosko, Louis Huzella, W. Dowling, A. Eakin, B. Osborn, Janet Gahagen, Liang V. Tang, C. Green, J. Mirsalis, M. Holbrook, P. Jahrling, J. Dyall, L. Hensley   +18 more
semanticscholar   +1 more source

Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

Pharmacogenomics and Personalized Medicine, 2020
Background In Eritrea, artesunate–amodiaquine is the first-line treatment against uncomplicated malaria. Amodiaquine, which is mainly bio-transformed by CYP2C8, is known to be associated with adverse events of different severity.
Lidia Habtemikael, Mulugeta Russom, I. Bahta, S. Mihreteab, Araia Berhane, A. Mårtensson, J. Gil   +6 more
semanticscholar   +1 more source

Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]

, 2013
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth, Joseph, Deokary, Kabanywanyi, Abdunoor M, Minzi, Omary Ms, Mugittu, Kefas, Premji, Zulfiqarali   +5 more
core   +3 more sources

Polimorfismos del gen pfmdr1 en muestras clínicas de Plasmodium falciparum y su relación con la respuesta terapéutica a antipalúdicos y paludismo grave en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. El gen pfmdr1 de Plasmodium falciparum se describió como un gen de resistencia a diversos antipalúdicos. Sin embargo, no se han estudiado el papel de su polimorfismo en la respuesta terapéutica al tratamiento con antipalúdicos en Colombia ...
Paula Montoya, Alberto Tobón, Silvia Blair, Jaime Carmona, Amanda Maestre   +4 more
doaj   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ-Pyrimidines.

ACS Medicinal Chemistry Letters, 2019
To evade the possible toxicity associated with the formation of quinone-imine metabolite in amodiaquine (AQ), the para-hydroxyl group was replaced with a -F atom, and the resulting 4'-fluoro-amodiaquine (FAQ) was hybridized with substituted pyrimidines ...
Mohit Tripathi, Dale Taylor, Shabana I. Khan, B. Tekwani, Prija Ponnan, U. Das, T. Velpandian, D. Rawat   +7 more
semanticscholar   +1 more source

Eficacia terapéutica y eventos adversos de tratamientos para malaria vivax y malaria falciparum en gestantes en las regiones de Urabá y Alto San Jorge, Colombia, 2008-2011 Therapeutic efficacy and adverse events of treatments for vivax and falciparum malaria in pregnant women in the regions of Uraba and Alto San Jorge, Colombia, 2008-2011

Revista Colombiana de Obstetricia y Ginecología, 2013
Objetivo: evaluar, con el protocolo de la Organización Mundial de la Salud (OMS) de 1998, la respuesta terapéutica antimalárica (RTA) y los eventos adversos (EA) en cuatro esquemas de tratamiento antiplasmodial en gestantes colombianas, con diagnóstico ...
Jaime Carmona-Fonseca, Olga María Agudelo-García, Eliana Arango-Flórez   +2 more
doaj  

Gametocytaemia in senegalese children with uncomplicated Falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine

Parasite, 2001
Plasmodium falciparum gametocytaemia was studied in 266 Senegalese children (median 4 years, range 0.5-16) with uncomplicated malaria treated with chloroquine (CQ), amodiaquine (AQ) or sulfadoxine+pyrimethamine (SP).
Sokhina C.S, Trape J.-F, Robert V.
doaj   +1 more source

Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América. Objetivo.
Jaime Carmona-Fonseca, Eliana Arango, Silvia Blair   +2 more
doaj   +1 more source