Results 91 to 100 of about 10,947 (204)

Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Pharmaceutical Sciences, 2016
Background: Chloroquine and amodiaquine are used in the prophylaxis and treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On the other hand, there is no promising hepatoprotective agent for prophylaxis or treatment of
Akram Jamshidzadeh, Reza Heidari, Farzaneh Abazari, Maral Ramezani, Forouzan Khodaei, Mohammad Mehdi Ommati, Maryam Ayarzadeh, Roya Firuzi, Arastoo Saeedi, Negar Azarpira, Asma Najibi
doaj   +1 more source

Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy

Scientific Reports, 2018
We investigated the effects of chloroquine (CQ) and amodiaquine (AQ) on AMPK phosphorylation in renal tubular cells in a diabetic environment in vivo and in vitro.
H. Jeong, J. Kang, H. Jun, Dong-Jin Kim, S. Park, Min-Ji Sung, J. Heo, D. Yang, Sang Ho Lee, So-Young Lee   +9 more
semanticscholar   +1 more source

Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali

Drugs in R&D, 2020
Background In 2006, the National Malaria Control Program in Mali recommended artemisinin-based combination therapy as the first-line treatment for uncomplicated malaria.
Karim Traoré, Seidina A. S. Diakité, Sekou Bah, Drissa S. Konaté, Djeneba Dabitao, Ibrahim Sanogo, Modibo Sangaré, Souleymane Dama, Bourama Keita, Mory Doumbouya, Merepen A. Guindo, Seydou Doumbia, Mahamadou Diakité   +12 more
doaj   +1 more source

Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine

Antimicrobial Agents and Chemotherapy, 2018
Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether ...
S. Walimbwa, M. Lamorde, C. Waitt, J. Kaboggoza, L. Else, P. Byakika-Kibwika, Alieu Amara, J. Gini, M. Winterberg, J. Chiong, J. Tarning, S. Khoo   +11 more
semanticscholar   +1 more source

Preparation and evaluation of mixed-ligand complexes of Cu (II) and Co (II) with amodiaquine hydrochloride and sulphamethazine

Journal of Applied Sciences and Environmental Management, 2018
Cu (ll) and Co (II) complexes of amodiaquine hydrochloride and sulphamethazine (AMOSUF) have been prepared and characterized by elemental analysis, molar conductivity, FTIR and electronic spectroscopy.
E.A. Enemose, E.E. Akporhonor, B Kpomah
doaj   +1 more source

Efficacy of artesunate–amodiaquine, dihydroartemisinin–piperaquine and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger

Malaria Journal, 2018
Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland South-East Asia represents today a major threat to global health.
F. Grandesso, O. Guindo, Lynda Woi Messe, Rockyath Makarimi, Aliou Traoré, Souleymane Dama, I. Laminou, J. Rigal, M. de Smet, O. Ouwe Missi Oukem-Boyer, O. Doumbo, A. Djimde, J. Etard   +12 more
semanticscholar   +1 more source

Amodiaquine Modulates Aggregation and Disassembly of Amyloid-β and Tau and Attenuates Neuroinflammatory Responses and Aβ Production

Pharmaceutics
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles, which synergistically accelerate disease progression.
Sinae Jang, Sujin Kim, Na-Hyun Kim, Soo Jung Shin, Vijay Kumar, Jeong Gyu Son, Minseok Lee, Choon-gil Kim, Eun-Kyung Lim, Hyunju Chung, Young Ho Koh, Yunkwon Nam, Minho Moon   +12 more
doaj   +1 more source

Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso

Malaria Journal, 2008
Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are ...
Meissner Peter, Coulibaly Boubacar, Mockenhaupt Frank P, Mandi Germain, Müller Olaf   +4 more
doaj   +1 more source

Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

Malaria Journal, 2018
Prompt, effective treatment of confirmed malaria cases with artemisinin-based combination therapy (ACT) is a cornerstone of malaria control. Maximizing adherence to ACT medicines is key to ensuring treatment effectiveness.
K. Banek, E. Webb, S. Smith, D. Chandramohan, S. Staedke   +4 more
semanticscholar   +1 more source

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz, 2007
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear.
Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola   +7 more
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