Results 81 to 90 of about 14,011 (208)

Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study [PDF]

, 2012
Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS)
Adekoya, J. A., Ajanaku, K. O., Ajani, O. O., Ehi-Eromosele, C. O., Obaleye, J. A., Ogunniran, K. O.   +5 more
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Mitochondrial Dysfunction Induced by a Novel Salicylate‐Based 1,2,3‐Triazole Salt With Potent Antileishmanial Activity

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
A novel salicylate‐based 1,2,3‐triazole salt was synthesized and demonstrated potent and selective activity against Leishmania amazonensis. The most active compound induced mitochondrial dysfunction without hemolytic effects. In silico analyses also suggested favorable pharmacokinetic properties and oral bioavailability.
Bruno A. De Oliveira, Ari Sérgio de Oliveira Lemos, João Pedro Reis Costa Bastos, Luciana Maria Ribeiro Antinarelli, Ana Luiza Ribeiro de Freitas, Raissa Guedes Mattosinhos Ribeiro, Adolfo Firmino da Silva Neto, Elaine Soares Coimbra, Adilson David Da Silva   +8 more
wiley   +1 more source

Production and characterization of different types of malaria pigment (hemozoin) and their potential use for screening for hemozoin inhibiting drugs [PDF]

, 2012
Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2012Malarial pigment, hemozoin, appears to modulate the immune system, however it remains controversial if it has stimulatory or inhibitory effects ...
Góis, Ana Margarida Ferreira, 1988-
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Use of area under the curve to evaluate the effects of antimalarial drugs on malaria associated anemia after treatment [PDF]

, 2011
To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria associated anemia (MAA), we use the area under curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude.
Fatunmbi, Bayo, Folarin, Onikepe A, Gbotosho, Grace O., Happi, Christian T., Michael, Obaro S, Okuboyejo, Titilope M, Sowunmi, Akintunde   +6 more
core   +1 more source

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

Costing Artemisinin-based Combination Therapy for Malaria in Tanzania [PDF]

, 2005
Malaria continues to be a major contributor to the burden of disease in Tanzania, with a prevalence of 33.39 percent nationally. As antimalarial resistance to sulfadoxine-pyrimethamine in Tanzania continues to grow, the government is in the process of ...
Derriennic, Yann, Wolf, Katherine
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Amodiaquine and Hepatitis

Annals of Internal Medicine, 1986
Excerpt To the editor: Prophylaxis of malaria by amodiaquine is dangerous (1, 2). At least 20 cases of amodiaquine-associated agranulocytosis have been discovered so far in Switzerland, and 12 of t...
openaire   +2 more sources

Evaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia. [PDF]

, 2006
The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P.
Angarita, B, Counihan, H, Gordillo, F, Guthmann, J P, Hamade, P, Hill, O, van den Broek, I   +6 more
core   +1 more source

Evaluation of the comparative efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine and artesunate-amodiaquine-chlorpheniramine (Artemoclo™) for the treatment of acute uncomplicated malaria in Nigerian children. [PDF]

, 2014
OBJECTIVE: To evaluate the comparative efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and artesunate-amodiaquine-chlorpheniramine (AQC) for the treatment of acute uncomplicated malaria among Southwest Nigerian children.
Ademowo, OG, Dada-Adegbola, HO, Falade, CO, Nash, O, Oguike, MC, Ogunkunle, OO   +5 more
core   +1 more source

Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug sensitivity. [PDF]

, 2016
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012 ...
Brooker, SJ, Conrad, MD, Dorsey, G, Kamya, MR, Legac, J, Nankabirwa, JI, Nsobya, SL, Rosenthal, PJ, Staedke, SG, Tukwasibwe, S, Tumwebaze, P, Wandera, B   +11 more
core   +3 more sources