Results 91 to 100 of about 14,011 (208)

Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Pharmaceutical Sciences, 2016
Background: Chloroquine and amodiaquine are used in the prophylaxis and treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On the other hand, there is no promising hepatoprotective agent for prophylaxis or treatment of
Akram Jamshidzadeh, Reza Heidari, Farzaneh Abazari, Maral Ramezani, Forouzan Khodaei, Mohammad Mehdi Ommati, Maryam Ayarzadeh, Roya Firuzi, Arastoo Saeedi, Negar Azarpira, Asma Najibi
doaj   +1 more source

Therapeutic Efficacy of Sulfadoxine-Pyrimethamine and Prevalence of Resistance Markers in Tanzania Prior to Revision of Malaria Treatment Policy: Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Mutations in Monitoring in Vivo Resistance. [PDF]

, 2004
Prior to the 2001 malarial treatment policy change in Tanzania, we conducted trials to assess the efficacy of sulfadoxine-pyrimethamine (SP) and the usefulness of molecular markers in monitoring resistance.
Abdulla, Salim, Beck, Hans-Peter, Kataraihya, Johannes, Lemnge, Martha, Malisa, Allen, Mshinda, Hassan, Mugittu, Kefas, Mwita, Alex, Ndejembi, Modesta, Nkya, Watoky, Premji, Zulfikar   +10 more
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Artesunate – amodiaquine combination therapy for falciparum malaria in young Gabonese children [PDF]

, 2007
BACKGROUND: Artesunate-amodiaquine combination for the treatment of childhood malaria is one of the artemisinin combination therapies (ACTs) recommended by National authorities in many African countries today.
Oyakhirome, Sunny, Pötschke, Marc, Schwarz, Norbert G., Dörnemann, Jenny, Laengin, Matthias, Salazar, Carmen Ospina, Lell, Bertrand, Kun, Jürgen F. J., Kremsner, Peter G., Grobusch, Martin P.   +9 more
core   +2 more sources

Preparation and evaluation of mixed-ligand complexes of Cu (II) and Co (II) with amodiaquine hydrochloride and sulphamethazine

Journal of Applied Sciences and Environmental Management, 2018
Cu (ll) and Co (II) complexes of amodiaquine hydrochloride and sulphamethazine (AMOSUF) have been prepared and characterized by elemental analysis, molar conductivity, FTIR and electronic spectroscopy.
E.A. Enemose, E.E. Akporhonor, B Kpomah
doaj   +1 more source

Amodiaquine Modulates Aggregation and Disassembly of Amyloid-β and Tau and Attenuates Neuroinflammatory Responses and Aβ Production

Pharmaceutics
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles, which synergistically accelerate disease progression.
Sinae Jang, Sujin Kim, Na-Hyun Kim, Soo Jung Shin, Vijay Kumar, Jeong Gyu Son, Minseok Lee, Choon-gil Kim, Eun-Kyung Lim, Hyunju Chung, Young Ho Koh, Yunkwon Nam, Minho Moon   +12 more
doaj   +1 more source

Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso

Malaria Journal, 2008
Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are ...
Meissner Peter, Coulibaly Boubacar, Mockenhaupt Frank P, Mandi Germain, Müller Olaf   +4 more
doaj   +1 more source

Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo

International Journal of Infectious Diseases, 2019
Background: Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy, and safety. Individuals carrying the CYP2C8*
Simon Marie Peko, Francine Ntoumi, Christevy Vouvoungui, David Nderu, Simon Charles Kobawila, Thirumalaisamy P. Velavan, Félix Koukouikila-Koussounda   +6 more
doaj   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
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Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

Pharmacogenomics and Personalized Medicine, 2020
Lidia Habtemikael,1 Mulugeta Russom,2 Iyassu Bahta,2 Selam Mihreteab,3 Araia Berhane,4 Andreas Mårtensson,1 Jose Pedro Gil1,5,6 1Department of Women’s and Children’s Health, International Maternal and Child Health (IMCH), Uppsala ...
Habtemikael L, Russom M, Bahta I, Mihreteab S, Berhane A, Mårtensson A, Gil JP   +6 more
doaj  

Phytochemical Screening and in vivo antioxidant activity of Ethanolic extract of caesalpinia bondus (L.) Roxb [PDF]

, 2012
Phytochemical screening, antioxidant activity in vivo and lipid peroxidation of 75 % ethanolic extract of young twigs and leaves of Caesalpinia bonduc were carried out by chemical test, and assessment of catalase and peroxidase activities and lipid ...
Akindahunsi , A. A, Ntube , C. A, Ogunlana , O. E, Ogunlana , O. O, Olagunju , J. A   +4 more
core   +1 more source