Results 61 to 70 of about 7,095 (171)

Amodiaquine Modulates Aggregation and Disassembly of Amyloid-β and Tau and Attenuates Neuroinflammatory Responses and Aβ Production

Pharmaceutics
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles, which synergistically accelerate disease progression.
Sinae Jang, Sujin Kim, Na-Hyun Kim, Soo Jung Shin, Vijay Kumar, Jeong Gyu Son, Minseok Lee, Choon-gil Kim, Eun-Kyung Lim, Hyunju Chung, Young Ho Koh, Yunkwon Nam, Minho Moon   +12 more
doaj   +1 more source

Cohort retention in seasonal malaria chemoprevention: an analysis of magnitude and associated factors in Northern Bahr el Ghazal, South Sudan

Frontiers in Malaria
BackgroundHealth interventions that require multi-dose regimens are most effective when all doses are taken. Adherence to a full three-day course of Sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) in all planned cycles of the annual seasonal malaria ...
Francis Okot, Norman Aweno, Ebenezer C. Ikechukwu, Abubaker Rom, Gerald Kabuye, Jamshed Khan, Anthony Kirabira, Atemthi Dhieu Dau, Amanya Jacob, Ezbon WApary, Simon Peter Katongole, Denis Mubiru, Chukwudi A. Nnaji   +12 more
doaj   +1 more source

Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria

Bulletin of the World Health Organization
OBJECTIVE: To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine.
Walter RJ Taylor, Dianne J Terlouw, Piero L Olliaro, Nicholas J White, Philippe Brasseur, Feiko O ter Kuile   +5 more
doaj   +1 more source

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz, 2007
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear.
Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola   +7 more
doaj  

Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice

Scientific African
Background: Malaria is a global health problem due to its high incidence of morbidity and mortality, especially in children and pregnant women. However, the Plasmodium parasite frequently develops resistance to chemotherapy, triggering continuous ...
Daniel Ampomah Frimpong, Aliu Moomin, Samuel Asare Nkansah, Aaron Opoku Antwi, Abubakar Ibn Sidik, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah   +6 more
doaj   +1 more source

Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections

CPT: Pharmacometrics & Systems Pharmacology
Artemisinin‐based combination therapy (ACT) is the first‐line recommended treatment for uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often based on small studies and need to be confirmed and validated in larger pregnant ...
Junjie Ding, Richard M. Hoglund, Harry Tagbor, Halidou Tinto, Innocent Valéa, Victor Mwapasa, Linda Kalilani‐Phiri, Jean‐Pierre Van Geertruyden, Michael Nambozi, Modest Mulenga, Sebastian Hachizovu, Raffaella Ravinetto, Umberto D'Alessandro, Joel Tarning   +13 more
doaj   +1 more source

PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Clinical and Translational Science
The urgent need for safe, efficacious, and accessible drug treatments to treat coronavirus disease 2019 (COVID‐19) prompted a global effort to evaluate drug repurposing opportunities.
Nada Abla, Lisa M. Almond, Jennifer J. Bonner, Naomi Richardson, Timothy N. C. Wells, Jörg J. Möhrle   +5 more
doaj   +1 more source

Hepatic responses as potential biomarkers of idiosyncratic drug reaction risk. [PDF]

Toxicol Sci
Liao J, Lyu X, Yang K, Chen L, Uetrecht J.   +4 more
europepmc   +1 more source

Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis. [PDF]

Chembiochem
Dhiman S, Manhas D, Jamwal A, Singh A, Kumar V, Vij B, Ojha PK, Singh SK, Ahmed Z, Nandi U.   +9 more
europepmc   +1 more source

Slowing the spread of treatment failure to artemisinin-based combination therapies in Uganda. [PDF]

Nat Commun
Nguyen TD, Zupko RJ, Conrad MD, Rukundo GB, Farinha CC, Asua VD, Tran KT, Grace DM, Rosenthal PJ, Agaba BB, Kamya MR, Opigo J, Boni MF.   +12 more
europepmc   +1 more source