Results 41 to 50 of about 10,947 (204)

Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination

Malaria Journal, 2009
Background Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen to Coartem® (artemether ...
Gustafsson Lars L, Mahindi Margarita, Mukonzo Jackson, Obua Celestino, Ntale Muhammad, Beck Olof, Ogwal-Okeng Jasper W   +6 more
doaj   +1 more source

Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine

Malaria Journal, 2012
Background Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination.
Adjei George O, Oduro-Boatey Collins, Rodrigues Onike P, Hoegberg Lotte C, Alifrangis Michael, Kurtzhals Jorgen A, Goka Bamenla Q   +6 more
doaj   +1 more source

Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy

Journal of Tropical Medicine, 2015
Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations ...
Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu   +2 more
doaj   +1 more source

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia

Malaria Journal, 2007
Background Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in Plasmodium falciparum antimalarial drug resistance.
Taylor Walter RJ, Olliaro Piero, Gonzalez Iveth, Osorio Lyda   +3 more
doaj   +1 more source

Eficacia de amodiaquina y sulfadoxina/pirimetamina en el tratamiento de malaria no complicada por Plasmodium falciparum en Nariño, Colombia, 1999-2002.

Biomédica: revista del Instituto Nacional de Salud, 2003
La resistencia a los antimaláricos es una de las causas del aumento de casos de malaria en el mundo. Desde el año 2000, el tratamiento de malaria no complicada por Plasmodium falciparum en Colombia ha sido la combinación de amodiaquina (AQ) y sulfadoxina/
Iveth J. González, Julio O. Padilla, Luis E. Giraldo, Nancy G. Saravia   +3 more
doaj   +1 more source

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Frontiers in Pharmacology, 2018
Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ).
Yongjie Zhang, Yongjie Zhang, Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Steven Hiemstra, Nico P. E. Vermeulen, Bob van de Water, Jan N. M. Commandeur, J. C. Vos   +8 more
doaj   +1 more source

Interactions between DNA purinic bases and amodiaquine: A theoretical approach

Orbital: The Electronic Journal of Chemistry, 2010
We study theoretically the amodiaquine-adenine and amodiaquine-guanine adducts formation using Density Functional Theory (B3LYP) and the 6-31G(d) basis set for the geometry optimizations and 6-31+G(d,p) for the analysis of the global indexes ...
Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz, Maria Lara Palmeira de Macedo Arguelho   +3 more
doaj   +1 more source

Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing

Communications Chemistry
Nuclear receptor-related 1 (Nurr1) is a promising candidate target for neurodegenerative disease treatment, however, the validation of their therapeutic potential remains underexplored due to a lack of high-quality chemical tools.
Minh Sai, Emily C Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A Marschner, Daniel Merk   +7 more
semanticscholar   +1 more source

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

Cell Death and Differentiation, 2019
Pharmacological inhibition of ribosome biogenesis is a promising avenue for cancer therapy. Herein, we report a novel activity of the FDA-approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate-limiting step for ribosome ...
Jaime A. Espinoza, A. Zisi, D. C. Kanellis, Jordi Carreras-Puigvert, M. Henriksson, D. Hühn, Kenji Watanabe, T. Helleday, M. Lindström, J. Bartek   +9 more
semanticscholar   +1 more source

Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury

Journal of Immunotoxicology, 2017
If idiosyncratic drug-induced liver injury (IDILI) is immune-mediated, it is possible that an individual’s prior exposure to antigens may affect their susceptibility to IDILI.
Alastair Mak, Alexander Johnston, Jack Uetrecht   +2 more
doaj   +1 more source