Results 41 to 50 of about 15,149 (207)

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

E-Journal of Chemistry, 2009
Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to ...
Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia   +2 more
doaj   +1 more source

Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children

Memorias do Instituto Oswaldo Cruz, 2008
Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction.
Akintunde Sowunmi, Sulayman T Balogun, Grace O Gbotosho, Christian T Happi   +3 more
doaj   +1 more source

Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]

, 2012
\ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Khatib, Rashid A, Lutambi, Angelina M, Masanja, Irene M   +2 more
core   +3 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

In vitro effects of amodiaquine on paired Schistosoma mansoni adult worms at concentrations of less than 5 µg/mL

Memorias do Instituto Oswaldo Cruz, 2013
In this study, the in vitro effects of amodiaquine (AQ) monotherapy on the egg output of paired adult Schistosoma mansoni worms and their survival during in vitro culture were assessed.
Kentaro Kato, Mitsumasa Miura, Yoshinori Mitsui   +2 more
doaj   +1 more source

Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum. [PDF]

PLoS ONE, 2015
The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance.
Chandima S K Rajapakse, Maryna Lisai, Christiane Deregnaucourt, Véronique Sinou, Christine Latour, Dipankar Roy, Joseph Schrével, Roberto A Sánchez-Delgado   +7 more
doaj   +1 more source

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. [PDF]

, 2018
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito ...
Bousema, Teun, Bradley, John, Brown, Joelle M, Chen, Ingrid, Diarra, Kalifa, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Hwang, Jimee, Issiaka, Djibrilla, Keita, Sekouba, Kone, Daouda T, Lanke, Kjerstin, Mahamar, Almahamoudou, McCulloch, Charles, Müller, Olaf, Roh, Michelle E, Sanogo, Koualy, Soumare, Harouna M, Srinivasan, Vinay, Stone, Will JR, Traore, Sekou F   +22 more
core   +2 more sources

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

Polimorfismos del gen pfmdr1 en muestras clínicas de Plasmodium falciparum y su relación con la respuesta terapéutica a antipalúdicos y paludismo grave en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. El gen pfmdr1 de Plasmodium falciparum se describió como un gen de resistencia a diversos antipalúdicos. Sin embargo, no se han estudiado el papel de su polimorfismo en la respuesta terapéutica al tratamiento con antipalúdicos en Colombia ...
Paula Montoya, Alberto Tobón, Silvia Blair, Jaime Carmona, Amanda Maestre   +4 more
doaj   +1 more source