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Amoebic keratitis is difficult to treat without total efficacy in some patients because of cysts, which is less susceptible than trophozoites to the usual treatments.
Erdogan Malatyali +2 more
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Nanomaterials quickly evolve to produce safe and effective biomedical alternatives, mainly silver nanoparticles (AgNPs). The AgNPs’ antibacterial, antiviral, and antitumor properties convert them into a recurrent scaffold to produce new treatment ...
Lucia Margarita Valenzuela-Salas +2 more
exaly +2 more sources
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Amoebicidal action and chemical constitution
Proceedings of the Royal Society of London. Series B - Biological Sciences, 1950Abstract This communication describes some of the results which have been obtained in the search for an amoebicidal agent which might replace emetine. Eighty-seven compounds have been synthesized starting from two 4-chloroquinolines with a methyl or anilino group in the 2-position.
J D, FULTON +4 more
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Plant extracts as natural amoebicidal agents
Parasitology Research, 2008Strains of Acanthamoeba sp. constitute a factor contributing to the occurrence of chronic granulomatous amoebic encephalitis, keratitis, pneumonia, as well as inflammations of other organs. Treatment of these diseases is very difficult and not always effective. A majority of these infections have been fatal.
Monika, Derda +2 more
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Comparative Evaluation of Amoebicidal Drugs
1974Amoebic infection often poses a therapeutic challenge. The physician has at his disposal a wide range of antiamoebic drugs having varying degrees of activity. Reports on the efficacy of these drugs are often contradictory [1, 2, 3, 4]. This may be, to some extent, due to natural variations of the disease in different regions, but is largely due to ...
B J, Vakil, N J, Dalal
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Amoebicidal Activity of Multipurpose Contact Lens Solutions
Eye & Contact Lens: Science & Clinical Practice, 2005To compare the amoebicidal activity of two commercially available multipurpose contact lens care systems, by using cyst and trophozoite growth of two strains each of Acanthamoeba castellanii and Acanthamoeba polyphaga.Trophozoites and cysts of Acanthamoeba species, isolated from corneal ulcers and an ATCC strain, were exposed to two commonly used ...
Sally L, Buck +2 more
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A novel plate assay method for amoebicides
Experientia, 1964Une nouvelle methode de culture d'amibes sur plaques d'agar (Figure 1) est avantageusement employee ici en vue de la detection rapide et facile de l'action antiamibienne directe des composes (Figures 2 et 3).
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IV. The search for new amoebicidal drugs
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1957Abstract 1. (1) Methods which have been used in a large industrial research department in the search for new amoebicides are discussed. 2. (2) New techniques of testing potential amoebicides in vitro and in an in vivo — in vitro tests in rats are described. 3. (3) Results of three tests used have been compared.
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Synthesis of diphenyl bisamidines as potential amoebicides
European Journal of Medicinal Chemistry, 1996Summary Various substituted diphenyl bisamidines were prepared and tested for antiamoebic activity in Golden hamsters and Wistar rats. Compounds 10 showed in vitro activity at 100 μg/mL and displayed excellent in vivo activity against hepatic infection in the hamster.
B Venugopalan +5 more
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The therapeutic efficency of a new amoebicide among prison inmates
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1960Abstract 1. 1) The insanitary conditions of the prison under which the present field test was performed do not make it the ideal subject for clinical trials as was originally supposed, owing to the high relapse and reinfection rate. These adverse reactions because of the environmental conditions did not detract from the value of the experiment ...
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