In vitro validation of the amoebicidal activity of commercial eye drops as second activity [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2021 The validation of anti-Acanthamoeba activity of commercial eye drops has gained a great interest recently and a growing number of commercials eye drop were evaluated for their aptitude to inhibit Acanthamoeba as a second pharmacological effect.
Olfa Chiboub +6 more
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The Amoebicidal Activity of Diferrocenyl Derivatives: A Significant Dependence on the Electronic Environment [PDF]
Molecules, 2023 Amoebiasis is the second leading cause of death worldwide associated with parasitic disease and is becoming a critical health problem in low-income countries, urging new treatment alternatives.
Yanis Toledano-Magaña +6 more
doaj +4 more sources
New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation [PDF]
Pharmaceutics, 2021 Nanomaterials quickly evolve to produce safe and effective biomedical alternatives, mainly silver nanoparticles (AgNPs). The AgNPs’ antibacterial, antiviral, and antitumor properties convert them into a recurrent scaffold to produce new treatment options.
Lucía Margarita Valenzuela-Salas +12 more
doaj +4 more sources
Potential Amoebicidal Activity of Hydrazone Derivatives: Synthesis, Characterization, Electrochemical Behavior, Theoretical Study and Evaluation of the Biological Activity [PDF]
Molecules, 2015 Four new hydrazones were synthesized by the condensation of the selected hydrazine and the appropriate nitrobenzaldehyde. A complete characterization was done employing 1H- and 13C-NMR, electrochemical techniques and theoretical studies.
Yanis Toledano-Magaña +9 more
doaj +4 more sources
Amoebicidal activity of milk, apo-lactoferrin, sIgA and lysozyme. [PDF]
Clin Med Res, 2006 To identify amoebicidal components in human milk and the effect of iron on the amoebicidal activity.Investigation in axenic cultures of Entamoeba histolytica trophozoites.Amoebas were treated with 5%-20% of human, bovine and swine milk, with 10% of human milk fractions (i.e., casein, proteins except casein and fat) or with 1 mg/ml of human milk apo ...
León-Sicairos N +5 more
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Amoebicidal activity of cationic carbosilane dendrons derived with 4-phenylbutyric acid against Acanthamoeba griffini and Acanthamoeba polyphaga trophozoites and cysts [PDF]
Scientific Reports, 2022 Amoebae from the genus Acanthamoeba are important pathogens responsible for severe illnesses in humans such as Acanthamoeba keratitis and granulomatous amoebic encephalitis. In the last few decades, AK diagnoses have steadily increased.
P. López-Barona +8 more
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Amoebicidal Activity of Poly-Epsilon-Lysine Functionalized Hydrogels. [PDF]
Invest Ophthalmol Vis Sci, 2022 To determine the amoebicidal activity of functionalized poly-epsilon-lysine hydrogels (pɛK+) against Acanthamoeba castellanii.A. castellanii trophozoites and cysts were grown in the presence of pɛK solution (0-2.17 mM), pɛK or pɛK+ hydrogels, or commercial hydrogel contact lens (CL) for 24 hours or 7 days in PBS or Peptone-Yeast-Glucose (PYG) media ...
Kennedy SM +7 more
europepmc +4 more sources
Iris setosa Pall. ex Link Extract Reveals Amoebicidal Activity against Acanthamoeba castellanii and Acanthamoeba polyphaga with Low Toxicity to Human Corneal Cells [PDF]
MicroorganismsAcanthamoeba keratitis (AK) is a sight-threatening and difficult-to-treat ocular infection. The significant side effects of current AK treatments highlight the urgent need to develop a safe and effective AK medication.
Hương Giang Lê +7 more
doaj +2 more sources
All you need is fungi: Exploring secondary metabolites as a source of novel amoebicidal agents [PDF]
Genetics and Molecular BiologyFree-living amoebae (FLAs) of the genus Acanthamoeba are opportunistic protozoa found in diverse environments. They can cause granulomatous amoebic encephalitis, especially in immunocompromised individuals, and Acanthamoeba keratitis, a painful corneal ...
Maria Eduarda Deluca João +7 more
doaj +3 more sources
Demethoxycurcumin exhibits amoebicidal activity against Acanthamoeba triangularis trophozoites and cysts and inhibits encystation [PDF]
Current Research in Parasitology and Vector-Borne DiseasesAcanthamoeba is a ubiquitous free-living protist commonly found in soil and water, with the T4 genotype responsible for most human infections. Treatment remains challenging due to the limited efficacy of current therapeutics and the parasite’s ability to
Rachasak Boonhok +16 more
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