Results 11 to 20 of about 1,069 (182)

Amoebicidal activity of benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentials

Acta Tropica, 2020
Acanthamoeba spp. are free-living amoebae isolated from many ecological areas such as swimming pools, dams and lakes, and soil. Granulomatous amebic encephalitis and amebic keratitis, caused by Acanthamoeba spp., usually occurs in chronically ill, debilitated individuals, in immunosuppressed patients and treatment is quite difficult.
Necati Özpinar, Hulya Özpinar, Tutku Tunc   +2 more
exaly   +5 more sources

Amoebicidal, anti-adhesive, and low-cytotoxic effects of Mangifera indica L. leaf extract against ocular Acanthamoeba spp.: First evidence supporting plant-based therapeutic potential [PDF]

Veterinary World
Background and Aim: Acanthamoeba spp. is free-living protozoa capable of causing severe infections, notably Acanthamoeba keratitis, which is difficult to manage due to cyst resistance and the cytotoxicity of current treatments.
Diana Mendonça, Hazel A. Tabo, Siriphorn Chimplee, Sónia M. R. Oliveira, Pattamaporn Kwankaew, Ana Paula Girol, Julieta Z. Dungca, Mazdida Sulaiman, Subha Bhassu, Muhammad Nawaz, Polrat Wilairatana, Christophe Wiart, Karma G. Dolma, Sunil Kayesth, Veeranoot Nissapatorn, Maria De Lourdes Pereira   +15 more
doaj   +3 more sources

Phragmites australis (Cav.) Trin. ex Steud. Extract Induces Apoptosis-like Programmed Cell Death in Acanthamoeba castellanii Trophozoites

Plants, 2022
Acanthamoeba keratitis (AK) is an infectious ocular disease which is difficult to diagnose correctly and cure. Development of an effective and safe therapeutic drug for AK is needed.
Hương-Giang Lê, Ji-Su Choi, Buyng-Su Hwang, Yong-Tae Jeong, Jung-Mi Kang, Tuấn-Cường Võ, Pyo-Yun Cho, Young-Kyung Lee, Won-Gi Yoo, Yeonchul Hong, Young-Taek Oh, Byoung-Kuk Na   +11 more
doaj   +2 more sources

Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica.

PLoS Neglected Tropical Diseases, 2011
BackgroundAmoebiasis is a major public health problem in tropical and subtropical countries. Currently, metronidazole is the gold choice medication for the treatment of this disease.
Simran Preet, Sanjay Bharati, Geeta Shukla, Ashwani Koul, Praveen Rishi   +4 more
doaj   +2 more sources

Amoebicidal activity of curcumin on Entamoeba histolytica trophozoites

Journal of Pharmacy and Pharmacology, 2018
Abstract Objectives This study was undertaken to investigate the amoebicidal potential of curcumin on Entamoeba histolytica, as well as its synergistic effect with metronidazole. Methods Entamoeba histolytica trophozoites were exposed
Itzia Azucena Rangel-Castañeda, José Manuel Hernández-Hernández, Armando Pérez-Rangel, Sirenia González-Pozos, Pilar Carranza-Rosales, Claudia Lisette Charles-Niño, Gabriela Tapia-Pastrana, Mario Alberto Ramírez-Herrera, Araceli Castillo-Romero   +8 more
openaire   +3 more sources

Investigation of In Vitro Amoebicidal Activities of Trachystemon orientalis on Acanthamoeba castellanii Cysts and Trophozoites

Van Tıp Dergisi, 2019
INTRODUCTION: Acanthamoeba species cause important diseases such as Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis.
Bülent Kaynak, Zeynep Kolören, Ülkü Karaman   +2 more
doaj   +2 more sources

Amoebicidal Activity of Caffeine and Maslinic Acid by the Induction of Programmed Cell Death in Acanthamoeba. [PDF]

Antimicrob Agents Chemother, 2017
ABSTRACT Free-living amoebae of the genus Acanthamoeba are the causal agents of a sight-threatening ulceration of the cornea called Acanthamoeba keratitis, as well as the rare but usually fatal disease granulomatous amoebic encephalitis.
Martín-Navarro CM, López-Arencibia A, Sifaoui I, Reyes-Batlle M, Fouque E, Osuna A, Valladares B, Piñero JE, Héchard Y, Maciver SK, Lorenzo-Morales J.   +10 more
europepmc   +5 more sources

Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by Acanthamoeba castellanii and Naegleria Fowleri [PDF]

Parasite Epidemiology and Control
Acanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Devandran Apparasamy, Niwasini Krishna Kumar, Chris Izaak Jones, Yee Mon Htet, Haema Thevanayagam, Usman Ahmed, Mohd Farooq Shaik, Ayaz Anwar, Kavitha Rajendran   +8 more
doaj   +2 more sources

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic encephalitis ...
Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng   +5 more
doaj   +2 more sources

Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-N-oxide derivatives against Giardia lamblia, Trichomonas vaginalis, and Entamoeba histolytica. An in vitro and in silico approach [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives were evaluated in vitro against Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), and Entamoeba histolytica (E. histolytica).
Alonzo González-González, Oscar Sánchez-Sánchez, Lilián Yépez-Mulia, Timoteo Delgado-Maldonado, Lenci K. Vázquez-Jiménez, Gabriel López-Velázquez, José Ignacio de la Mora-de la Mora, Sebastian Pacheco-Gutierrez, Laura Chino-Ríos, Diego Arias, Adriana Moreno-Rodríguez, Alma Paz-González, Eyra Ortíz-Pérez, Gildardo Rivera   +13 more
doaj   +2 more sources