Advances in Biomedical and Health Sciences, 2022 Background: Acanthamoeba castellanii genotype T4 is the causative agent of the progressively increasing sight-threatening Acanthamoeba keratitis and central nervous system infections.
Noor Akbar +6 more
doaj +1 more source
GalNAc Carbohydrate Prevents the Formation of Neutrophil Extracellular Traps and Increase Myeloperoxidase Enzyme Activity in Interactions of Neutrophils and Entamoeba histolytica Preincubated With GalNAc. [PDF]
Biomed Res IntDuring amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of adhesion between E.
Levaro-Loquio D +8 more
europepmc +2 more sources
Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation. [PDF]
Angew Chem Int Ed EnglA pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Zhang S +7 more
europepmc +3 more sources
Phenotypic assay for cytotoxicity assessment of Balamuthia mandrillaris against human neurospheroids
Frontiers in Microbiology, 2023 IntroductionThe phenotypic screening of drugs against Balamuthia mandrillaris, a neuropathogenic amoeba, involves two simultaneous phases: an initial step to test amoebicidal activity followed by an assay for cytotoxicity to host cells.
Narisara Whangviboonkij +7 more
doaj +1 more source
Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone
Antibiotics, 2022 Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf +6 more
doaj +1 more source
The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials
Advanced NanoBiomed Research, Volume 3, Issue 12, December 2023., 2023 ε‐poly‐l‐lysine (ε‐PLL) is a natural polypeptide originating from bacteria with strong antifungal and antibacterial properties. ε‐PLL is highly used to develop antimicrobial materials and as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics.
Eloïse Lebaudy +4 more
wiley +1 more source
Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications
WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 3, May/June 2023., 2023 Carbosilane dendritic systems are unique tools for the therapy, prevention, and diagnosis of multiple diseases. They can be precisely designed for the specific purpose, thus maximizing the biological activity. Abstract Dendrimers are multifunctional molecules with well‐defined size and structure due to the step‐by‐step synthetic procedures required in ...
Francisco Javier de la Mata +5 more
wiley +1 more source
Statins Induce Actin Cytoskeleton Disassembly and an Apoptosis-Like Process in Acanthamoeba spp.
Antibiotics, 2022 Acanthamoeba is a ubiquitous opportunistic protozoan pathogen that is known to cause blinding keratitis and rare, but usually fatal, granulomatous encephalitis.
Rubén L. Rodríguez-Expósito +5 more
doaj +1 more source
Anti-Acanthamoeba activity of a semi-synthetic mangostin derivative and its ability in removal of Acanthamoeba triangularis WU19001 on contact lens [PDF]
PeerJ, 2022 Garcinia mangostana L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin.
Julalak Chuprom +15 more
doaj +2 more sources
<i>Mentha rotundifolia</i>, a Source of Amoebicidal Agents Against <i>Naegleria fowleri</i>. [PDF]
Int J Mol SciCurrent therapies for Primary Amoebic Meningoencephalitis (PAM) present several limitations; consequently, there is an urgent need to develop new therapeutic agents.
Ben Youssef M +9 more
europepmc +2 more sources