Artemether Exhibits Amoebicidal Activity against Acanthamoeba castellanii through Inhibition of the Serine Biosynthesis Pathway. [PDF]
Antimicrob Agents Chemother, 2015 Deng Y +7 more
europepmc +2 more sources
Plants, 2022 Acanthamoeba keratitis (AK) is an infectious ocular disease which is difficult to diagnose correctly and cure. Development of an effective and safe therapeutic drug for AK is needed.
Hương-Giang Lê +11 more
doaj +1 more source
In vitro amoebicidal activity of immune cells [PDF]
Infection and Immunity, 1982 The amoebicidal activity of peripheral blood lymphocytes and spleen and peritoneal cells from hamsters vaccinated against or protected from hepatic amoebiasis and from those with hepatic amoebiasis was investigated. Peripheral blood lymphocytes and peritoneal and spleen cells from vaccinated or protected animals can kill trophozoites of Entamoeba ...
E, Ghadirian, E, Meerovitch
openaire +2 more sources
Advances in Biomedical and Health Sciences, 2022 Background: Acanthamoeba castellanii genotype T4 is the causative agent of the progressively increasing sight-threatening Acanthamoeba keratitis and central nervous system infections.
Noor Akbar +6 more
doaj +1 more source
GalNAc Carbohydrate Prevents the Formation of Neutrophil Extracellular Traps and Increase Myeloperoxidase Enzyme Activity in Interactions of Neutrophils and Entamoeba histolytica Preincubated With GalNAc. [PDF]
Biomed Res IntDuring amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of adhesion between E.
Levaro-Loquio D +8 more
europepmc +2 more sources
Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation. [PDF]
Angew Chem Int Ed EnglA pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Zhang S +7 more
europepmc +3 more sources
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 The genus Acanthamoeba is characterized by being a group of ubiquitous and free-living amoebae that inhabit a variety of environments. Generally, human infections by this parasite are associated with Acanthamoeba keratitis, especially in contact lens ...
R. Rodríguez-Expósito +6 more
semanticscholar +1 more source
Phenotypic assay for cytotoxicity assessment of Balamuthia mandrillaris against human neurospheroids
Frontiers in Microbiology, 2023 IntroductionThe phenotypic screening of drugs against Balamuthia mandrillaris, a neuropathogenic amoeba, involves two simultaneous phases: an initial step to test amoebicidal activity followed by an assay for cytotoxicity to host cells.
Narisara Whangviboonkij +7 more
doaj +1 more source
Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone
Antibiotics, 2022 Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf +6 more
doaj +1 more source
The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials
Advanced NanoBiomed Research, Volume 3, Issue 12, December 2023., 2023 ε‐poly‐l‐lysine (ε‐PLL) is a natural polypeptide originating from bacteria with strong antifungal and antibacterial properties. ε‐PLL is highly used to develop antimicrobial materials and as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics.
Eloïse Lebaudy +4 more
wiley +1 more source