A novel anticancer natural product SP09 selectively targets KRAS-mutant NSCLC through LKB1/AMPK/mTOR modulation: implications for novel therapeutic development. [PDF]
Anticancer DrugsYue P +5 more
europepmc +1 more source
Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue
iNew Medicine, EarlyView.ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao +3 more
wiley +1 more source
Metabolic crossroads in insulin resistance: exploring lipid dysregulation and inflammation. [PDF]
Front ImmunolSaadati S +4 more
europepmc +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
An update on regulation of the polymodal TRPV4 channel by protein phosphorylation. [PDF]
Channels (Austin)Parthasarathy A, Zhang DX.
europepmc +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
<i>Cornus controversa</i> Leaf and Stem Extract Attenuates LPS-Induced Inflammatory Responses in RAW 264.7 Macrophages via NF-κB/MAPK Inhibition and AMPK Activation. [PDF]
J Microbiol BiotechnolChoi SY +5 more
europepmc +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari +3 more
wiley +1 more source
[Expression of Concern] Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway. [PDF]
Mol Med RepMeng HY +6 more
europepmc +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen +2 more
wiley +1 more source