Results 261 to 270 of about 114,592 (304)

AMP‐activated protein kinase and cancer

Acta Physiologica, 2009
AbstractAMP‐activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Elevated AMP/ATP ratio activates AMPK, which inhibits energy‐consuming processes and activates energy‐producing processes to restore the energy homeostasis inside the cell.
W, Wang, K-L, Guan
openaire   +2 more sources

AMP‐activated protein kinase ‐ An archetypal protein kinase cascade?

BioEssays, 1992
AbstractMammalian AMP‐activated protein kinase is the central component of a protein kinase cascade which inactivates three key enzymes involved in the synthesis or release of free fatty acids and cholesterol inside the cell. The kinase cascade is activated by elevation of AMP, and perhaps also by fatty acid and cholesterol metabolites.
D G, Hardie, R W, MacKintosh
openaire   +2 more sources

AMP‐activated Protein Kinase

2003
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted.
openaire   +3 more sources

New targets of AMP-activated protein kinase

Biochemical Society Transactions, 2003
The discovery of the AMP-activated protein kinase (AMPK) more than a decade ago has shed much light on the cellular response to stresses characterized by a fall in the concentration of ATP and an increase in the AMP/ATP ratio. All conditions known to increase this ratio activate AMPK, whose major role is to act as an emergency signal to conserve ATP ...
L, Hue   +8 more
openaire   +2 more sources

AMP-activated protein kinase: nature's energy sensor

Nature Chemical Biology, 2011
Maintaining sufficient levels of ATP (the immediate source of cellular energy) is essential for the proper functioning of all living cells. As a consequence, cells require mechanisms to balance energy demand with supply. In eukaryotic cells the AMP-activated protein kinase (AMPK) cascade has an important role in this homeostasis. AMPK is activated by a
David, Carling   +3 more
openaire   +2 more sources

AMP-activated protein kinase in the brain

International Journal of Obesity, 2008
Since its discovery as an important regulator of fuel utilization in the periphery, AMP-activated protein kinase (AMPK) has become a contender for many important cell-intrinsic and organismal roles regarding energy balance in the central nervous system.
G V, Ronnett, S, Aja
openaire   +2 more sources

AMP-activated protein kinase, super metabolic regulator

Biochemical Society Transactions, 2003
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
B E, Kemp   +13 more
openaire   +2 more sources

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