Results 71 to 80 of about 114,592 (304)

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]

, 2016
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S., de Jesus Perez, Vinicio, MacLean, Margaret, West, James D.   +3 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Roles of Hydrogen Sulfide Donors in Common Kidney Diseases

Frontiers in Pharmacology, 2020
Hydrogen sulfide (H2S) plays a key role in the regulation of physiological processes in mammals. The decline in H2S level has been reported in numerous renal disorders.
Ebenezeri Erasto Ngowi, Ebenezeri Erasto Ngowi, Ebenezeri Erasto Ngowi, Muhammad Sarfraz, Muhammad Sarfraz, Muhammad Sarfraz, Muhammad Sarfraz, Attia Afzal, Attia Afzal, Attia Afzal, Nazeer Hussain Khan, Nazeer Hussain Khan, Saadullah Khattak, Saadullah Khattak, Xin Zhang, Xin Zhang, Tao Li, Tao Li, Shao-Feng Duan, Shao-Feng Duan, Shao-Feng Duan, Xin-Ying Ji, Xin-Ying Ji, Xin-Ying Ji, Dong-Dong Wu, Dong-Dong Wu, Dong-Dong Wu   +26 more
doaj   +1 more source

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation [PDF]

, 2013
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while ...
Ahmadian, An, Anthony, Arita, Arkan, Bain, Barnes, Barré, Bauwens, Berggreen, Bourron, Boyle, Boyle, Brooks, Buhl, Carey, Carling, Carling, Caton, Chakrabarti, Chaves, Chavez, Chen, Chen, Cheung, Cinti, Cool, Coppari, Daval, Daval, Ducharme, Duncan, Dzamko, Egan, Emerling, Eringa, Fazakerley, Fischer, Fisher, Flechtner-Mors, Foretz, Fox, Fryer, Gaidhu, Gaidhu, Gaidhu, Gaidhu, Galic, Garton, Gauthier, Gauthier, Geraghty, Giri, Glass, Grimaldi, Guigas, Gurriarán-Rodríguez, Gustafson, Habinowski, Hardie, Hawley, Hawley, Hawley, Henin, Hevener, Holmes, Hutchinson, Huypens, Ian P. Salt, Iglesias, Imamura, Iwatsubo, Jeon, Jeong, Jiao, Kanda, Kelly, Kim, Kitade, Koh, Kohlstedt, Koistinen, Kola, Kou, Kramer, Kristensen, Lee, Lee, Li, Lihn, Lihn, Lin, Lin, Liu, Lorente-Cebrián, Luo, López, Lönnqvist, MacDougald, Martínez-Agustin, Marzolla, McBride, McGee, McInnes, McInnes, Minokoshi, Mulligan, Narkar, Nguyen, Nishimura, Nishimura, Odegaard, Ojuka, Ojuka, Orci, Pagnon, Park, Peng, Perrotti, Peyton, Polakof, Pulinilkunnil, Rasmussen, Reihill, Reshef, Reshef, Rosen, Saberi, Sag, Sakamoto, Sakamoto, Sakaue, Sakoda, Salt, Salt, Salt, Samovski, Sano, Sarah J. Mancini, Schwenk, Scott, Shi, Silvia Bijland, Solinas, Sponarova, Steinberg, Steinberg, Su, Sullivan, Sun, Takekoshi, Tam, Tang, Turer, Vandanmagsar, Vats, Vaughan, Vila-Bedmar, Villena, Vingtdeux, Viollet, Vucetic, Wan, Wang, Wang, Wang, Watt, Winder, Woods, Wu, Xiao, Xu, Yamauchi, Yang, Yin, Yuen, Zhang, Zhang, Zhang, Zhang, Zhou, Zimmermann, Zmijewski   +182 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Journal of Lipid Research, 2013
ETC-1002 is an investigational drug currently in Phase 2 development for treatment of dyslipidemia and other cardiometabolic risk factors. In dyslipidemic subjects, ETC-1002 not only reduces plasma LDL cholesterol but also significantly attenuates levels
Sergey Filippov, Stephen L. Pinkosky, Richard J. Lister, Catherine Pawloski, Jeffrey C. Hanselman, Clay T. Cramer, Rai Ajit K. Srivastava, Timothy R. Hurley, Cheryl D. Bradshaw, Mark A. Spahr, Roger S. Newton   +10 more
doaj   +1 more source

Activation of Ciona sperm motility: phosphorylation of dynein polypeptides and effects of a tyrosine kinase inhibitor [PDF]

, 1991
A high molecular mass dynein ATPase polypeptide and a 18–20 kDa dynein light chain of Ciona sperm flagella are phosphorylated during in vivo activation of motility or in vitro activation of motility by incubation with cyclic AMP.
Brokaw, Charles J., Dey, Chinmoy S.
core