Results 131 to 140 of about 2,417 (187)

Anti‐Modified Protein Antibodies in Rheumatoid Arthritis: Pathogenic, Protective, or Passive Bystander?

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The presence of anti‐modified protein antibodies (AMPA) is a hallmark of rheumatoid arthritis (RA). AMPA recognize post‐translationally modified proteins and are cross‐reactive. AMPA include anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA).
Amber‐Sarai F. L. Stalman, Diane van der Woude   +1 more
wiley   +1 more source

Estradiol Replacement Modulates Synaptic Transmission‐Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
The estrogen deficiency in the hippocampus influences cognitive functions and control of food intake. Hippocampi of female rats, either control or ovariectomized, with or without estrogen replacement, were submitted to LC–MS/MS and analysis of pathway‐based functional roles of proteins affected by estrogen deficiency and replacement.
Amanda Paula Pedroso, Adriana Pereira Souza, Guilherme Araújo Câmara, Meira Maria Forcellini Machado, Valter Tadeu Boldarine, Lila Missae Oyama, Mônica Marques Telles, Alexandre Keiji Tashima, Eliane Beraldi Ribeiro   +8 more
wiley   +1 more source

Changes in Aperiodic (1/f Slope) Activity During a Picture‐Word Interference Task: Effects of Congruency and Sequence Manipulations

Psychophysiology, Volume 63, Issue 8, August 2026.
ABSTRACT Aperiodic neural activity (1/f EEG) has been proposed to reflect the balance between excitatory and inhibitory (E/I) inputs, with steeper spectral slopes reflecting increased inhibition and flatter slopes indicating excitation. This activity is also thought to reflect the temporal coordination of neural firing, offering insights into ...
Virginia Tronelli, Patrycja Kałamała, Gabriele Gratton, Monica Fabiani, Mate Gyurkovics, Kathy A. Low, Maurizio Codispoti, Andrea De Cesarei   +7 more
wiley   +1 more source

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

Reorganization of synchronous and asynchronous release in developing hippocampal autaptic neurons of mice

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Presynaptic vesicle pools, particularly the readily releasable pool (RRP), are essential for synaptic transmission. The RRP comprises fast‐release pool (FRP) and slow‐release pool (SRP) subpopulations that mediate synchronous and asynchronous neurotransmitter release, respectively, yet their developmental regulation remains unclear.
Kouya Uchino, Hiroyuki Kawano, Risako Fujikawa, Takuya Watanabe, Katsunori Iwasaki, Shin‐Ya Kawaguchi, Shutaro Katsurabayashi   +6 more
wiley   +1 more source

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AMPA Receptor Antagonists

Current Medicinal Chemistry, 2001
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
S S, Nikam, B E, Kornberg
openaire   +2 more sources

Competitive AMPA Receptor Antagonists

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA, COLOTTA, VITTORIA, VARANO, FLAVIA   +2 more
openaire   +3 more sources

In Search of Novel AMPA Potentiators

Recent Patents on CNS Drug Discovery, 2006
Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation.
Francotte, Pierre, De Tullio, Pascal, Fraikin, Pierre, Counerotte, Stéphane, Goffin, Eric, Pirotte, Bernard   +5 more
openaire   +2 more sources

RNA aptamers for AMPA receptors

Neuropharmacology, 2021
RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Zhen Huang, Li Niu
openaire   +2 more sources

Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding

European Journal of Pharmacology, 1997
AMPA receptors can be labeled using the agonist radioligands [3H](R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H](R,S)-AMPA), [3H](S)-AMPA or [3H](S)-5-fluorowillardiine. In the presence of KSCN, [3H](R,S)-AMPA and [3H](S)-AMPA bind to a single population of sites in rat brain membranes, whereas [3H](S)-5-fluorowillardiine binds ...
Jon E Hawkinson
exaly   +3 more sources