Results 1 to 10 of about 48,039 (217)

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]

Cellular and Molecular Life Sciences, 2019
To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the ...
Diane Bissen, , Acker-Palmer Amparo
exaly   +4 more sources

Allosteric competition and inhibition in AMPA receptors. [PDF]

Nat Struct Mol Biol, 2023
Abstract Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through
Hale WD, Montaño Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC.   +6 more
europepmc   +4 more sources

Regulating AMPA Receptors with Isoxazole-4-Carboxamide Derivatives: An Electrophysiological Study [PDF]

Journal of Xenobiotics
Isoxazole carboxamide derivatives are intriguing modulators of ionotropic glutamate receptors; more specifically, their prospective analgesic activities based on non-opioid pathways have sparked widespread research.
Mohammad Qneibi, Mohammed Hawash, Sosana Bdir, Mohammad Bdair, Tala Idais, Iyas Sarhan, Joud Touqan   +6 more
doaj   +2 more sources

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

Biomolecules, 2020
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj   +3 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

Cells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi, Safa’ Nassar, Sosana Bdir, Adel Hidmi   +3 more
doaj   +1 more source

AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases [PDF]

Cellular and Molecular Neurobiology
Zafaruddin Khan
exaly   +2 more sources

SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]

PLoS ONE, 2013
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero, Sabine M Blankenship, Yun Shi, Roger A Nicoll   +3 more
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj   +1 more source

Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]

PLoS ONE, 2012
Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov, Tommi Möykkynen, Sarah K Coleman, Esa R Korpi, Kari Keinänen   +4 more
doaj   +1 more source

Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses

Frontiers in Synaptic Neuroscience, 2021
The amygdala plays a crucial role in attaching emotional significance to environmental cues. Its intercalated cell masses (ITC) are tight clusters of GABAergic neurons, which are distributed around the basolateral amygdala complex.
Anna Seewald, Sabine Schönherr, Heide Hörtnagl, Ingrid Ehrlich, Ingrid Ehrlich, Claudia Schmuckermair, Francesco Ferraguti   +6 more
doaj   +1 more source