Results 1 to 10 of about 6,053 (169)

GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration [PDF]

Cell Reports, 2021
Summary: Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons ...
Jonathan Soboloff, Amit Agarwal, Masahiro Fukaya   +2 more
exaly   +5 more sources

When Does ALS Start? ADAR2?GluA2 Hypothesis for the Etiology of Sporadic ALS [PDF]

Frontiers in Molecular Neuroscience, 2011
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Shin Kwak, Kwak Shin
exaly   +5 more sources

Activity-based anorexia enhances glutamatergic synaptic transmission and neuronal excitability within the nucleus accumbens of female mice. [PDF]

Physiol Rep
Abstract Anorexia nervosa is a severe psychiatric disorder characterized by persistent food restriction and often excessive physical activity, implicating dysfunction in neural circuits governing motivation, reward, and behavioral persistence. The nucleus accumbens (NAc) is a central component of these circuits, yet synaptic and cellular adaptations ...
Bailey LG, Christensen CW, Weed SE, Islam MM, Thakar A, Brown JB, Hentges ST, Brown TE.   +7 more
europepmc   +2 more sources

Comparative Cochlear-Vestibular Aging Reveals Age-Aligned Mitochondrial Ultrastructural Burden, Mitophagy-Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline. [PDF]

Aging Cell
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Xie J, Zhang X, Tian J, Yan Y, Shi K, Pan Y, Zhang Y, Chen Z, Sun J, Lv H, Chen J, Ren X, Kamogashira T, Zhang X, Gao Y.   +14 more
europepmc   +2 more sources

Thiazole Derivatives as Modulators of GluA2 AMPA Receptors: Potent Allosteric Effects and Neuroprotective Potential

Biomolecules, 2023
Thiazole carboxamide derivatives were synthesized in this investigation, with a subsequent examination of their impact on GluA2 AMPA receptors. The synthesized compounds, namely MMH-1-5, were subjected to characterization using high-resolution mass ...
Mohammed Hawash, Hawash Mohammed
exaly   +3 more sources

Functional Ca2+-permeable AMPA receptors in hippocampal astrocytes mediate calcium signaling in vitro [PDF]

Scientific Reports
Glutamate is the main excitatory neurotransmitter in the brain, acting through ionotropic receptors such as AMPA receptors (AMPARs). While their neuronal role is well established, AMPAR function in astrocytes remains poorly understood, especially in the ...
Javier Picañol, Aida Castellanos, Esther Gratacòs-Batlle, Roberto García, Silvia Ginés, Xavier Gasull, Lydia Jiménez-Díaz, Juan D. Navarro-López, David Soto   +8 more
doaj   +2 more sources

Synaptic Inhibition in the Accessory Olfactory Bulb Regulates Pheromone Location Learning and Memory. [PDF]

FASEB Bioadv
ABSTRACT Pheromone signaling is pivotal in driving the social and reproductive behaviors of rodents. Learning and memorizing the pheromone locations involve olfactory subsystems. To study the neural basis of this behavior, we trained female heterozygous knockouts of GluA2 (AMPAR subunit) and NR1 (NMDAR subunit), targeting GAD65 interneuron population ...
Marathe SD, Pandey S, Rawat D, Das S, Abraham NM.   +4 more
europepmc   +2 more sources

Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity [PDF]

The Journal of Clinical Investigation
The increased prevalence of GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs) at spinal cord sensory synapses amplifies nociceptive transmission and maintains chronic neuropathic pain.
Meng-Hua Zhou, Shao-Rui Chen, Daozhong Jin, Yuying Huang, Hong Chen, Guanxing Chen, Jiusheng Yan, Hui-Lin Pan   +7 more
doaj   +2 more sources

Emotional stress increases GluA2 expression and potentiates fear memory via adenylyl cyclase 5

Cell Reports
Summary: Stress can alter behavior and contributes to psychiatric disorders by regulating the expression of the GluA2 AMPA receptor subunit. We have previously shown in mice that exposure to predator odor stress elevates GluA2 transcription in cerebellar
Siqiong June Liu
exaly   +3 more sources

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

Molecular Neurodegeneration, 2023
Background RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q).
Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce Vissel   +15 more
doaj   +1 more source