Results 1 to 10 of about 7,660 (199)

FSC231 alleviates paclitaxel‐induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK‐3β and ERK1/2

Brain and Behavior, 2021
Background FSC231, a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of protein kinase Cα interacting protein 1 (PICK1), has analgesic effects, but the mechanism remains unclear.
Xi Zhang, Jiagao Wang, Ran Ran, Yuchuan Peng, Yun Xiao   +4 more
doaj   +1 more source

Diurnal Regulation of Hippocampal Synaptic Plasticity in Aged Rats and the Role of the Circadian Clock Gene Per1

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Period circadian regulator 1 (PER1) regulates circadian gene expression and is critical for spatial memory. However, its role in regulating synaptic plasticity between diurnal phases remains largely unknown. Here, we examined long‐term potentiation (LTP) and long‐term synaptic depression (LTD) in hippocampal slices prepared from aged male Per1
Liam T. Ralph, Shinwon Kang, Lauren A. Joe, Patrick Tidball, Ahmad R. Israwi, Meng Tian, Ashish Kadia, Lijia Zhang, Fuzi Jin, Rachael Ingram, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway‐Campbell, Joanne E. Nash, Janice Robertson, Clarrisa A. Bradley, Marina Gertsenstein, Lauryl M. J. Nutter, John Georgiou, Graham L. Collingridge   +19 more
wiley   +1 more source

Acute stress induces contrasting changes in AMPA receptor subunit phosphorylation within the prefrontal cortex, amygdala and hippocampus. [PDF]

PLoS ONE, 2010
Exposure to stress causes differential neural modifications in various limbic regions, namely the prefrontal cortex, hippocampus and amygdala. We investigated whether α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) phosphorylation ...
Dorian Caudal, Bill P Godsil, François Mailliet, Damien Bergerot, Thérèse M Jay   +4 more
doaj   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors

Glia, Volume 74, Issue 8, August 2026.
In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Tessa E. Allen, Graham Peet, Luis E. Gomez Wulschner, Won Chan Oh, Wendy B. Macklin   +4 more
wiley   +1 more source

Advancement of Peptide‐PAINT: Applications and Current Challenges in Super‐Resolution Imaging

Small Science, Volume 6, Issue 8, August 2026.
Peptide‐PAINT is rapidly emerging as a powerful single‐molecule super‐resolution imaging platform, enabling molecular visualization with ~5–10 nm localization precision. This review critically discusses its underlying principles, recent biological applications, technological limitations, and key challenges, while benchmarking its strengths and ...
Devi Prasanna Behera, Ritesh Sonar, Ahenjeeta Ghosh, Barun Kumar Maity   +3 more
wiley   +1 more source

Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Objective The neurovascular unit (NVU) is a core structural and functional entity involved in migraine pathogenesis. Acupuncture may exert therapeutic effects by protecting NVU integrity. This narrative review aims to summarize the current evidence on the mechanisms by which acupuncture protects the NVU in migraine.
Yajie Wang, Chao Zhang, Linbo Shen, Yuanyuan Wang, Xiaocheng Wang, Linjing Song, Li Wang, Ningle Zhang, Dayong Ma, Tao Xiong   +9 more
wiley   +1 more source

Homer 1 gene products orchestrate Ca2+-permeable AMPA receptor distribution and LTP expression

Frontiers in Synaptic Neuroscience, 2012
We studied the role of Homer1 gene products on the presence of synaptic Ca2+-permeable AMPA receptors (AMPARs) and LTP generation in hippocampal CA1 pyramidal neurons, using mice that either lacked all Homer1 isoforms (Homer1 KO) or overexpressed the ...
Andrei eRozov, Aleksandar eZivkovic, Martin K Schwarz   +2 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Reprogramming lipid metabolism for cognitive restoration in Alzheimer's via PLA2G4E

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Growing evidence implicates dysregulated brain lipid metabolism in Alzheimer's disease (AD) pathogenesis, influencing membrane integrity, neuroinflammation, and amyloid beta and tau pathology, thereby representing a promising therapeutic target.
Sara Badesso, María Espelosín, Cristina Alonso, Alejandro Montilla, Maria Collantes, Mar Cuadrado‐Tejedor, Ana García‐Osta   +6 more
wiley   +1 more source