GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration [PDF]
Cell Reports, 2021 Summary: Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons ...
Jonathan Soboloff +2 more
exaly +5 more sources
When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS [PDF]
Frontiers in Molecular Neuroscience, 2011 Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Takuto eHideyama +3 more
doaj +5 more sources
GluA2 is rapidly edited at the Q/R site during neural differentiation in vitro [PDF]
Frontiers in Cellular Neuroscience, 2015 The majority of AMPA receptors in the adult brain contain GluA2 subunits, which can be edited at the Q/R site, changing a glutamine to an arginine within the ion pore.
Svenja ePachernegg +10 more
doaj +5 more sources
Reduction in membrane AMPA receptor subunit 2 in left prefrontal cortex correlates with post-stroke depression [PDF]
NeurotherapeuticsPost-stroke depression (PSD) is a prevalent and debilitating complication of stroke. While ischemic lesion in left prefrontal cortex (PFC) is a recognized risk factor, the underlying mechanisms linking this locus to PSD remain poorly defined. The α-amino-
Yipeng Yu, Rong Fu, Haokun Rong, Qi Fang
doaj +2 more sources
Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2 [PDF]
The Journal of Neuroscience, 2011 AMPA receptors (AMPARs) are postsynaptic glutamate-gated ion channels that mediate fast excitatory neurotransmission in the mammalian brain. Synaptic activity modulates the density of synaptic AMPARs, thereby affecting synaptic function, learning, and ...
Katherine W. Roche +2 more
core +3 more sources
GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons [PDF]
Molecular and Cellular Neuroscience, 2014 AMPA-type glutamate receptors mediate fast, excitatory neurotransmission in the brain, and their concentrations at synapses are important determinants of synaptic strength.
Keles, Mehmet F +7 more
core +6 more sources
Epileptic seizures and synaptic network dysfunctions in GluA2 autoimmune encephalitis [PDF]
, 2023 The term autoimmune encephalitis (AE) covers a group of neurological disorders in which autoantibodies (aABs) target distinct neuronal surface antigens, leading to cognitive dysfunction, confusion, psychotic symptoms, and seizures.
Yuan, Yang
core +2 more sources
GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
Frontiers in Molecular Neuroscience, 2012 The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov +2 more
doaj +2 more sources
PLoS ONE, 2012 AMPA receptors lacking the GluA2 subunit allow a significant influx of Ca(2+) ions. Although Ca(2+)-permeable AMPA receptors are a familiar feature at early stages of development, the functional significance of these receptors during the maturation of ...
Yone J Yoon +4 more
doaj +2 more sources
α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors [PDF]
eLifeAMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the mammalian brain. Their efficacy in responding to presynaptic glutamate release depends on their kinetics, which are determined by AMPARs and their auxiliary subunit ...
Rixu Cong +14 more
doaj +2 more sources