Results 1 to 10 of about 128,689 (159)

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

PLoS ONE, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A Rogawski   +3 more
doaj   +13 more sources

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function [PDF]

Journal of Xenobiotics
Background: Fast excitatory transmission in the central nervous system is carried out by AMPA-type glutamate receptors. Neuronal hyperexcitability and epilepsy have been associated with the dysregulation of AMPA receptor function.
Sosana Bdir, İrfan Çapan, Mohammed Hawash, Süleyman Servi, Mohammad Qneibi   +4 more
doaj   +2 more sources

The role of hydration in the removal of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) by nanofiltration membranes [PDF]

Nature Communications
Nanofiltration can remove glyphosate (GLY) and aminomethylphosphonic acid (AMPA) from water via steric, Donnan, and dielectric exclusions, although the significance of dielectric exclusion resulting from hydration has not been elucidated.
Phuong B. Trinh, Minh N. Nguyen, Zdenek Futera, Babak Minofar, Marco Personeni, Poul B. Petersen, Andrea I. Schäfer   +6 more
doaj   +2 more sources

Basil (Ocimum basilicum) Leaves Essential Oil Ameliorates GluR1 Receptor Expression, TNF-α Level, and Pain-like Behaviors in Post-operative Pain Setting

Bali Journal of Anesthesiology, 2022
Background: Unrelieved post-operative pain is an emerging healthcare concern with ever increasing global volume of surgical procedures. GluR1 subunit coupled with tumor necrosis factor (TNF)-α expression plays a major role in the development of post ...
Dewa Ayu Mas Shintya Dewi, Made Jawi, Nyoman Mantik Astawa, Christopher Ryalino   +3 more
doaj   +1 more source

Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil [PDF]

Pharmaceutical Sciences Asia, 2022
Clitoria ternatea (butterfly pea) flower and Eugenia caryophyllus (clove) oil have been traditionally used as hair growth stimulating herbal and exhibited hair growth effects in vitro. This work prepared liposome loading with butterfly pea flower extract
Natchaporn Choochuen, Ampa Jimtaisong
doaj   +1 more source

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

Biomolecules, 2020
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj   +1 more source

Новый взгляд на патогенез депрессии: возможно ли появление быстродействующих антидепрессантов?

Современная терапия психических расстройств, 2020
Рекуррентное депрессивное расстройство является одним из самых распространенных и высокозатратных психических заболеваний в мире. На настоящий момент актуальна моноаминовая теория депрессии, однако открытие около 20 лет назад антидепрессивных свойств
Мосолов, С.Н., Федорова, Е.Ю.   +1 more
doaj   +1 more source

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Scientific Reports, 2021
Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits minimal ...
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura   +11 more
doaj   +1 more source

Aluminium and calcium lake pigments of Lac natural dye

Brazilian Journal of Pharmaceutical Sciences, 2020
This work presents the physicochemical properties of the prepared lac lakes. The study revealed the stability, cytotoxicity and use of lac lake pigment as a cosmetic colorant. SEM, XRD and DSC were used to study the characteristics of the lac lakes.. The
Ampa Jimtaisong
doaj   +1 more source

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Arthritis Research & Therapy, 2021
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is
Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer, René E. M. Toes   +16 more
doaj   +1 more source