Results 21 to 30 of about 2,417 (187)

Influence of glyphosate and its metabolite aminomethylphosphonic acid on aquatic plants in different ecological niches

Ecotoxicology and Environmental Safety, 2022
Glyphosate and its metabolite aminomethylphosphonic acid (AMPA) draw great concern due to their potential threat to aquatic ecosystems. The individual and combined effects of glyphosate and AMPA on aquatic plants in different ecological niches need to be
Mengjie Qu, Longtao Wang, Qiang Xu, Jiaqi An, Yunjun Mei, Guanglong Liu   +5 more
doaj   +1 more source

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
J, Keifer, Z, Zheng
openaire   +2 more sources

The adhesion modulation protein, AmpA localizes to an endocytic compartment and influences substrate adhesion, actin polymerization and endocytosis in vegetative Dictyostelium cells

BMC Cell Biology, 2012
Background AmpA is a secreted 24Kd protein that has pleiotropic effects on Dictyostelium development. Null mutants delay development at the mound stage with cells adhering too tightly to the substrate.
Noratel Elizabeth F, Petty Chere’ L, Kelsey Jessica S, Cost Hoa N, Basappa Nisha, Blumberg Daphne D   +5 more
doaj   +1 more source

Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices

Scientific Reports, 2023
Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AMPA dose-dependently inhibited carbachol (CCH)-
Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu   +11 more
doaj   +1 more source

Progesterone monitoring and gestation length in Amazonian manatees (Trichechus inunguis)

Theriogenology Wild
Knowledge of pregnancy length and the physiological parameters during pregnancy is an important tool for pregnancy diagnosis in free-ranging and captive individuals and for the correct husbandry of captive pregnant females. Therefore, this study aimed to
Rodrigo S. Amaral, Vera M.F. da Silva, José Anselmo d’Affonsêca Neto   +2 more
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj   +1 more source

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Molecular Neurodegeneration, 2018
Background Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic ...
Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman, John R. Cirrito   +4 more
doaj   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source