Results 41 to 50 of about 70,772 (270)

Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior [PDF]

, 2001
Stimuli paired with primary rewards can acquire emotional valence and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions
Rudolf N. Cardinal, Di Ciano, Patricia, Patricia Di Ciano, Cowell, Rosemary A., Rosie A. Cowell, Barry J. Everitt, Cardinal, Rudolf N., Simon J. Little, Little, Simon J., Everitt, Barry J.   +9 more
core   +1 more source

Influence of glyphosate and its metabolite aminomethylphosphonic acid on aquatic plants in different ecological niches

Ecotoxicology and Environmental Safety, 2022
Glyphosate and its metabolite aminomethylphosphonic acid (AMPA) draw great concern due to their potential threat to aquatic ecosystems. The individual and combined effects of glyphosate and AMPA on aquatic plants in different ecological niches need to be
Mengjie Qu, Longtao Wang, Qiang Xu, Jiaqi An, Yunjun Mei, Guanglong Liu   +5 more
doaj   +1 more source

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
J, Keifer, Z, Zheng
openaire   +2 more sources

The adhesion modulation protein, AmpA localizes to an endocytic compartment and influences substrate adhesion, actin polymerization and endocytosis in vegetative Dictyostelium cells

BMC Cell Biology, 2012
Background AmpA is a secreted 24Kd protein that has pleiotropic effects on Dictyostelium development. Null mutants delay development at the mound stage with cells adhering too tightly to the substrate.
Noratel Elizabeth F, Petty Chere’ L, Kelsey Jessica S, Cost Hoa N, Basappa Nisha, Blumberg Daphne D   +5 more
doaj   +1 more source

Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices

Scientific Reports, 2023
Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AMPA dose-dependently inhibited carbachol (CCH)-
Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu   +11 more
doaj   +1 more source

Agonist occupancy is essential for forward trafficking of AMPA receptors.

, 2009
Regulated trafficking of AMPA receptors to cell surface and to synapses is an important determinant of neuronal excitability. In the present study, we have addressed the role of agonist binding and desensitization in the early trafficking of glutamate ...
Coleman, S.K., Jouppila, A., Möykkynen, T., Keinänen, K., Koskelainen, S., Korpi, E.R., Rivera, C.   +6 more
core   +1 more source

Progesterone monitoring and gestation length in Amazonian manatees (Trichechus inunguis)

Theriogenology Wild
Knowledge of pregnancy length and the physiological parameters during pregnancy is an important tool for pregnancy diagnosis in free-ranging and captive individuals and for the correct husbandry of captive pregnant females. Therefore, this study aimed to
Rodrigo S. Amaral, Vera M.F. da Silva, José Anselmo d’Affonsêca Neto   +2 more
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj   +1 more source

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Molecular Neurodegeneration, 2018
Background Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic ...
Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman, John R. Cirrito   +4 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source