Results 21 to 30 of about 7,660 (199)
Mechanistic Study of Schisandrin B in Alleviating Anxiety-Like Behaviors in Rats via Enhancement of Hippocampal Synaptic Plasticity and Restoration of the Intestinal Barrier. [PDF]
Food Sci NutrSchisandrin B ameliorates stress‐provoked anxiety‐like behaviors in rats via restoring intestinal barrier tight‐junction integrity, balancing hippocampal glutamate‐GABA neurotransmission, and promoting hippocampal synaptic plasticity. ABSTRACT This study focused on examining the anxiolytic effects of Schisandrin B (SchB) in rats exhibiting anxiety‐like
Tian JY +7 more
europepmc +2 more sources
From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function. [PDF]
J NeurochemKIBRA (WWC1) has been the subject of scientific interest since its initial association with nonpathological variation in human memory performance. This review discusses subsequent work in animal models demonstrating that KIBRA supports memory function.
Volk LJ.
europepmc +2 more sources
Comparative Cochlear-Vestibular Aging Reveals Age-Aligned Mitochondrial Ultrastructural Burden, Mitophagy-Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline. [PDF]
Aging CellThis study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Xie J +14 more
europepmc +2 more sources
IUCrJ, 2018 The AMPA receptor GluA2 belongs to the family of ionotropic glutamate receptors, which are responsible for most of the fast excitatory neuronal signalling in the central nervous system. These receptors are important for memory and learning, but have also
Andreas Haahr Larsen +7 more
doaj +2 more sources
In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2 [PDF]
Cell Reports, 2018 Summary: The functional role of AMPA receptor (AMPAR)-mediated synaptic signaling between neurons and oligodendrocyte precursor cells (OPCs) remains enigmatic. We modified the properties of AMPARs at axon-OPC synapses in the mouse corpus callosum in vivo
Ting-Jiun Chen +6 more
doaj +2 more sources
Biomolecules, 2023 Thiazole carboxamide derivatives were synthesized in this investigation, with a subsequent examination of their impact on GluA2 AMPA receptors. The synthesized compounds, namely MMH-1-5, were subjected to characterization using high-resolution mass ...
Mohammed Hawash
exaly +3 more sources
Functional Ca2+-permeable AMPA receptors in hippocampal astrocytes mediate calcium signaling in vitro [PDF]
Scientific ReportsGlutamate is the main excitatory neurotransmitter in the brain, acting through ionotropic receptors such as AMPA receptors (AMPARs). While their neuronal role is well established, AMPAR function in astrocytes remains poorly understood, especially in the ...
Javier Picañol +8 more
doaj +2 more sources
Brain and BehaviorBackground Clinical studies have confirmed that electroacupuncture (EA) has the potential to improve spasticity after intracerebral hemorrhage (ICH), yet its precise mechanism remains unclear.
Xudong Lu +9 more
doaj +3 more sources
Biochemical Journal, 2011 peer reviewedPositive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer’s disease.
Lars Olsen +21 more
core +5 more sources
AntioxidantsChronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored.
Lixue Chen +2 more
exaly +3 more sources