Results 31 to 40 of about 7,660 (199)

Emotional stress increases GluA2 expression and potentiates fear memory via adenylyl cyclase 5

Cell Reports
Summary: Stress can alter behavior and contributes to psychiatric disorders by regulating the expression of the GluA2 AMPA receptor subunit. We have previously shown in mice that exposure to predator odor stress elevates GluA2 transcription in cerebellar
Qian Yang, Ahmad Abdulla, Muhammad Farooq, Yoshihiro Ishikawa, Siqiong June Liu   +4 more
doaj   +2 more sources

The Frmpd3 Protein Regulates Susceptibility to Epilepsy by Combining with GRIP and GluA2

Current Issues in Molecular Biology
Frmpd3 (FERM and PDZ Domain Containing 3), a scaffold protein potentially involved in excitatory synaptic function, has not been thoroughly characterized in terms of its expression and functional role in vivo.
Yan Jia, Jinqiong Zhan, Pengcheng Huang, Xiaobing Li, Daojun Hong, Xi Lu   +5 more
doaj   +3 more sources

Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

Molecular Pharmacology, 2014
The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory synaptic transmission in the central nervous system.
Strømgaard, Kristian, Lucas, Simon, Poulsen, Mette Homann, Kristensen, Anders Skov   +3 more
core   +3 more sources

Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity [PDF]

The Journal of Clinical Investigation
The increased prevalence of GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs) at spinal cord sensory synapses amplifies nociceptive transmission and maintains chronic neuropathic pain.
Meng-Hua Zhou, Shao-Rui Chen, Daozhong Jin, Yuying Huang, Hong Chen, Guanxing Chen, Jiusheng Yan, Hui-Lin Pan   +7 more
doaj   +2 more sources

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

Molecular Neurodegeneration, 2023
Background RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q).
Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce Vissel   +15 more
doaj   +1 more source

Liposomal Encapsulated FSC231, a PICK1 Inhibitor, Prevents the Ischemia/Reperfusion-Induced Degradation of GluA2-Containing AMPA Receptors

Pharmaceutics, 2021
Strokes remain one of the leading causes of disability within the United States. Despite an enormous amount of research effort within the scientific community, very few therapeutics are available for stroke patients.
Lindsay M. Achzet, Fanny Astruc-Diaz, Phillip H. Beske, Nicholas R. Natale, Travis T. Denton, Darrell A. Jackson   +5 more
doaj   +1 more source

Estradiol rapidly increases GluA2‐mushroom spines and decreases GluA2‐filopodia spines in hippocampus CA1 [PDF]

Hippocampus, 2017
AbstractHippocampal dendritic spine density rapidly increases following estradiol (E2) treatment, but the types of spines and trafficking of synaptic markers have received little investigation. We assessed rapid effects of E2 over time on the density of four spine types (stubby, filopodial, long thin, and mushroom) and trafficking of AMPA receptor ...
Jorge A. Avila, Amber A. Alliger, Brigett Carvajal, Roseanna M. Zanca, Peter A. Serrano, Victoria N. Luine   +5 more
openaire   +2 more sources

Role of Site-Specific N-Glycans Expressed on GluA2 in the Regulation of Cell Surface Expression of AMPA-Type Glutamate Receptors. [PDF]

PLoS ONE, 2015
The AMPA-type glutamate receptor (AMPAR), which is a tetrameric complex composed of four subunits (GluA1-4) with several combinations, mediates the majority of rapid excitatory synaptic transmissions in the nervous system.
Yusuke Takeuchi, Jyoji Morise, Ippei Morita, Hiromu Takematsu, Shogo Oka   +4 more
doaj   +1 more source

Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke

Cell Reports, 2023
Summary: Synaptotagmin III (Syt3) is a Ca2+-dependent membrane-traffic protein that is highly concentrated in synaptic plasma membranes and affects synaptic plasticity by regulating post-synaptic receptor endocytosis.
Haifeng Lu, Shujun Chen, Qianqian Nie, Qun Xue, Hua Fan, Yiqing Wang, Shenghao Fan, Juehua Zhu, Haitao Shen, Haiying Li, Qi Fang, Jianqiang Ni, Gang Chen   +12 more
doaj   +1 more source

Disruption of GluA2 phosphorylation potentiates stress responsivity [PDF]

Behavioural Brain Research, 2017
Cocaine addiction is characterized by persistent craving and addicts frequently relapse even after long periods of abstinence. Exposure to stress can precipitate relapse in humans and rodents. Stress and drug use can lead to common alterations in synaptic plasticity and these commonalities may contribute to the ability of stress to elicit relapse ...
Alexandra S, Ellis, Anne Q, Fosnocht, Kelsey E, Lucerne, Lisa A, Briand   +3 more
openaire   +2 more sources