Results 51 to 60 of about 7,660 (199)

Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors

Frontiers in Cellular Neuroscience, 2022
Synaptic plasticity is essential for cognitive functions such as learning and memory. One of the mechanisms involved in synaptic plasticity is the dynamic delivery of AMPA receptors (AMPARs) in and out of synapses.
Li Chen, Hanjie Wang, Shuhan Cha, Jiong Li, Jiaqi Zhang, Jiaming Wu, Jiaming Wu, Guoqing Guo, Jifeng Zhang   +8 more
doaj   +1 more source

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

Neurobiology of Disease, 2012
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset fatal motor neuron disease. In spinal motor neurons of patients with sporadic ALS, normal RNA editing of GluA2, a subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Takuto Hideyama, Takenari Yamashita, Hitoshi Aizawa, Shoji Tsuji, Akiyoshi Kakita, Hitoshi Takahashi, Shin Kwak   +6 more
doaj   +1 more source

Gating of GluA2 Receptors is Mediated by a Pivot in the M3 Helix [PDF]

Biophysical Journal, 2013
Closure of the ligand-binding domain (LBD) of glutamate receptor channels opens their gate by a mechanism that is not fully clear. We find that glycine substitutions of pore facing residues in the conserved SYTANLAAF region in the transmembrane M3 helix of GluA2 improve gating.
Moore, Bryn S., Ebersole, Tonya L., Mirshahi, Uyenlinh L., Mirshahi, Tooraj   +3 more
openaire   +1 more source

Homomeric GluA2(R) AMPA receptors can conduct when desensitized [PDF]

Nature Communications, 2019
Abstract Desensitization is a canonical property of ligand-gated ion channels, causing progressive current decline in the continued presence of agonist. AMPA-type glutamate receptors (AMPARs), which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization. Recent cryo-EM studies of AMPAR assemblies show
Ian D. Coombs, David Soto, Thomas P. McGee, Matthew G. Gold, Mark Farrant, Stuart G. Cull-Candy   +5 more
openaire   +5 more sources

Analysis of Oligomer Assembly for the GluA2 Amino Terminal Domain [PDF]

Biophysical Journal, 2012
For GluA2, an ionotropic glutamate receptor that mediates excitatory synaptic transmission at CNS synapses, the reported monomer-dimer Kd of the amino-terminal domain (ATD) varies widely, ranging from 1.8 nM to 4 μM.1-3 To investigate causes of discrepancies in the literature, several protein constructs, diverse in glycosylation and overall size, were ...
Berger, Anthony J., Brown, Patrick, Zhao, Huaying, Schuck, Peter, Mayer, Mark   +4 more
openaire   +1 more source

Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking

Neuropharmacology, 2016
Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event leads to the internalization of ...
Lisa A. Briand, Andre U. Deutschmann, Alexandra S. Ellis, Anne Q. Fosnocht   +3 more
openaire   +3 more sources

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2 [PDF]

Biophysical Journal, 2016
The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer's disease. The modulators bind in a cleft formed by the interface of two neighboring ligand binding domains and act by stabilizing the ...
Krintel, Christian, Francotte, Pierre, Pickering, Darryl S., Juknaite, Lina, Pøhlsgaard, Jacob, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Pirotte, Bernard, Kastrup, Jette   +9 more
openaire   +4 more sources

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

eLife, 2017
Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner, Eva HH Albers, Nicolas Gutierrez-Castellanos, Niels R Reinders, Aile N van Huijstee, Hui Xiong, Tessa R Lodder, Helmut W Kessels   +7 more
doaj   +1 more source

Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.

PLoS ONE, 2013
Group II metabotropic glutamate receptor (mGluR) agonists have emerged as potential treatment drugs for schizophrenia and other neurological disorders, whereas the mechanisms involved remain elusive. Here we examined the effects of LY379268 (LY37) on the
Min-Juan Wang, Yan-Chun Li, Melissa A Snyder, Huaixing Wang, Feng Li, Wen-Jun Gao   +5 more
doaj   +1 more source

Mutually Dependent Clustering of SynDIG4/PRRT1 and AMPA Receptor Subunits GluA1 and GluA2 in Heterologous Cells and Primary Neurons

Frontiers in Molecular Neuroscience, 2022
Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at synapses is a predominant mechanism for regulating synaptic strength.
Kristopher E. Plambeck, Chun-Wei He, Hector H. Navarro, Elva Díaz   +3 more
doaj   +1 more source