Results 61 to 70 of about 7,660 (199)
Journal of Neuroinflammation, 2018 Background Hyperammonemic rats reproduce the cognitive alterations of patients with hepatic encephalopathy, including altered spatial memory, attributed to altered membrane expression of AMPA receptor subunits in hippocampus.
Lucas Taoro-Gonzalez +3 more
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Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]
PLoS ONE, 2017 AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya +6 more
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Biophysical Studies on Glua2 Ligand-Binding Domain Dimerization in Solution [PDF]
Biophysical Journal, 2013 AMPA receptors (GluAs) are essential neuronal ligand-gated ion channels involved in learning and memory. The dimeric conformation of the GluA2 ligand-binding domain is involved in the coupling of agonist binding to channel gating. The desensitized state conformation has been shown to be disrupted along the dimer interface, however little is known about
Ptak, Christopher P. +3 more
openaire +1 more source
GluA2 expression in LTP-stimulated rats.
, 2014 (a) Representative Western blot showing GluA2 (upper) and tubulin (lower) expression in laser microdissected tissue from one LTP-stimulated animal.
Wickliffe C. Abraham (153143) +4 more
core +1 more source
Analysis of GluA2 ATD dimer dissociation kinetics measured by FRET.
, 2013 (A) Decay of emission at 603 nm after addition of 1 µM unlabeled GluA2 (arrow) to a pre-equilibrated mix of 50 nM Dylight488-GluA2 ATD and 50 nM AF568-GluA2 ATD; the red line shows a single exponential fit of time constant 169 s, with decay to 64% of the
Carla Glasser (498485) +4 more
core +1 more source
Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit [PDF]
, 2018 AMPA receptor (AMPAR) trafficking is a key determinant of synaptic strength and synaptic plasticity. Under basal conditions, constitutive trafficking maintains surface AMPARs by internalization into the endosomal system, where the majority are sorted and
Chamberlain, Sophie E L +11 more
core +1 more source
Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy
Epilepsy Research, 2022 Recent studies have identified that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exerts multiple functions besides its role in energy metabolism. It can form a protein complex with GluA2 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), translocate into nucleus and confer neurotoxicity in a cerebral ischemia model.
Jinghui, Zhang +3 more
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Frontiers in Aging Neuroscience, 2014 GluA1, GluA2, GluA3, and GluA4 are the constitutive subunits of AMPA receptors (AMPARs), the major mediators of fast excitatory transmission in the mammalian central nervous system.
Pamela eCantanelli +12 more
doaj +1 more source
Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States [PDF]
Cell, 2014 Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory signaling in the nervous system. Despite the profound importance of iGluRs to neurotransmission, little is known about the structures and dynamics of intact receptors in distinct functional states.
Dürr, Katharina L. +7 more
openaire +3 more sources
Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors
Frontiers in Synaptic Neuroscience, 2018 The GluA2 subunit of AMPA glutamate receptors (AMPARs) has been shown to be critical for the expression of NMDA receptor (NMDAR)-dependent long-term depression (LTD).
Feng Cao +10 more
doaj +1 more source