Results 81 to 90 of about 7,660 (199)
Annals of the Child Neurology Society, EarlyView.ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata +9 more
wiley +1 more source
Comparison of the sw isotherm of Dylight488-GluA2 ATD with that of FAM-GluA2 ATD.
, 2013 (A) Dilution series of Dylight488-GluA2 ATD (open squares and triangles show data from two different runs) with a global best-fit single component, single class of sites model (bold black line) which leads to estimates of KD = 19.4 nM, s1 = 3.52 S, and ...
Carla Glasser (498485) +4 more
core +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
The utility of the term ‘Rett‐like’ in relation to Rett syndrome: A systematic review
Developmental Medicine &Child Neurology, EarlyView.Our findings show that ‘Rett‐like’ generally describes females with developmental disability, typically with no period of regression. We establish that there is a broad genetic landscape encompassing this disorder. Clinical utility of ‘Rett‐like’ is limited, with inadequate evidence of validity and diagnostic use of ‘Rett‐like’.
Anahita Khot, Daniel E Lumsden
wiley +1 more source
N-glycan at N370 of GluA2 regulates the intracellular trafficking of GluA1.
, 2015 (A) GluA1 and GluA2 (WT, N256S, N370S, or N413S) were transfected into HEK293 cells. GluA1 and GluA2 were immunoprecipitated with anti-GluA1 (right) and anti-GluA2/3 (middle) polyclonal antibodies, respectively, and then immunoblotted with each antibody.
Shogo Oka (782881) +4 more
core +1 more source
The FEBS Journal, EarlyView.GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen +4 more
wiley +1 more source
N-glycan at N370 is essential for cell surface expression of GluA2.
, 2015 (A) GluA2 is composed of NTD (pink), LBD (blue), transmembrane domains, and a cytoplasmic domain. NTD includes two N-glycosylation sites (N256 and N370), and N406 and N413 are located in the linker between NTD and LBD.
Shogo Oka (782881) +4 more
core +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang +8 more
wiley +1 more source
Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation [PDF]
Nature Neuroscience, 2010 Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion events and stabilization of surface ...
Evers, Danielle M. +6 more
openaire +2 more sources
, 2013 NMDA receptor activation promotes endocytosis of AMPA receptors, which is an important mechanism underlying long-term synaptic depression. The pH-sensitive GFP variant pHluorin fused to the N terminus of GluA2 (pH-GluA2) has been used to assay NMDA ...
Anggono, Victor +9 more
core +1 more source