Results 91 to 100 of about 7,660 (199)
Frontiers in Behavioral Neuroscience, 2015 Environmental enrichment (EE) housing paradigms have long been shown beneficial for brain function involving neural growth and activity, learning and memory capacity, and for developing stress resiliency. The expression of the α-amino-3-hydroxy-5-methyl-
Roseanna M Zanca +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen +11 more
wiley +1 more source
Validity of pHluorin-tagged GluA2 as a reporter for AMPA receptor surface expression and endocytosis [PDF]
Proceedings of the National Academy of Sciences, 2014 The recent paper by Rathje et al. (1) questions the interpretation of previous studies using super ecliptic pHluorin-GluA2 (SEP-GluA2) to monitor AMPA receptor surface expression and particularly its use as a reporter of endocytosis following NMDA or AMPA receptor stimulation.
Wilkinson, Kevin A +2 more
openaire +3 more sources
Cortical development of AMPA receptor trafficking proteins
Frontiers in Molecular Neuroscience, 2012 AMPA-receptor trafficking plays a central role in excitatory plasticity, especially during development. Changes in the number of AMPA receptors and time spent at the synaptic surface are important factors of plasticity that directly affect long-term ...
Kathryn M Murphy +3 more
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Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu +5 more
wiley +1 more source
The HNK-1 epitope on N-glycan at N413 enhances cell surface expression of GluA2.
, 2015 (A) A cell biotinylation assay was applied to HEK293 cells expressing GluA2 (WT, N256S, or N413S) with (+) or without (-) HNK-1-synthesizing enzymes (GlcAT-P and HNK-1ST).
Shogo Oka (782881) +4 more
core +1 more source
Stoichiometry of GluA1/GluA2 Heteromer of AMPA Receptor [PDF]
Biophysical Journal, 2021 Mukhopadhyay, Antara +2 more
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Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors [PDF]
Molecular Brain, 2017 Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhances long-term memory and LTP. Thus, multiple lines of evidence suggest a significant role for persistently elevated
Yu, N +7 more
openaire +3 more sources
Frontiers in Immunology, 2021 Antibodies recognizing the amino-terminal domain of receptor subunit proteins modify the receptor efficiency to controlling transmitter release in isolated nerve endings (e.g., synaptosomes) indirectly confirming their presence in these particles but ...
Francesca Cisani +11 more
doaj +1 more source
LY37 increased GluA2 surface expression in the cultured PFC neurons.
, 2013 (A) Representative immunofluorescent images of GluA2 receptor surface expression in response to a 60 min exposure to 0.1, 1, 10, or 100 µM LY37 treatment. Culture medium served as a vehicle control.
Huaixing Wang (402224) +5 more
core +1 more source