Synaptic Distributions of GluA2 and PKMζ in the Monkey Dentate Gyrus and Their Relationships with Aging and Memory [PDF]
The Journal of Neuroscience, 2012 Rhesus monkeys provide a valuable model for studying the neurobiological basis of cognitive aging, because they are vulnerable to age-related memory decline in a manner similar to humans. In this study, young and aged monkeys were first tested on a well characterized recognition memory test (delayed nonmatching-to-sample; DNMS).
Yuko, Hara +6 more
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The HNK-1 epitope expressed on GluA2 enhances cell surface expression of GluA1.
, 2015 A cell biotinylation assay was applied to HEK293 cells expressing GluA1 with (+) or without (-) GluA2 or HNK-1-synthesizing enzymes (GlcAT-P and HNK-1ST) as indicated.
Shogo Oka (782881) +4 more
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Consecutive corticosterone pulses differentially influence GluA2-AMPAR trafficking.
, 2016 (A) Representative trajectory (10–50 s duration) of surface GluA2 before and after the first pulse of corticosterone (peak at 100 nM). Scale bars represent 5 μm.
Natasha Pasricha (844217) +7 more
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PLoS ONE, 2013 GluA2-containing AMPA receptors and their association with protein kinase M zeta (PKMζ) and post-synaptic density-95 (PSD-95) are important for learning, memory and synaptic plasticity processes. Here we investigated these synaptic markers in the context
Veronica Sebastian +4 more
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Acute stress increases synaptic clustering of GluA2, PKMζ and PSD-95 in hippocampus.
, 2013 (A) Co-IP of PKMζ with PSD-95 significantly increased (n = 6 control, 8 stress), as did (B) Co-IP of PSD-95 with GluA2 (n = 5 control, 8 stress) and (C) Co-IP of PKMζ with GluA2 (n = 6 control, 6 stress). Overall levels of PSD-95 (D) or GluA2 (E) did not
Veronica Sebastian (476615) +4 more
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Control of AMPA receptor activity by the extracellular loops of auxiliary proteins
eLife, 2017 At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for
Irene Riva +4 more
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The role of AMPA receptor GluA2 subunit Q/R site RNA editing in the normal and Alzheimer’s diseased brain [PDF]
, 2014 Alzheimer’s disease (AD) is described by the build up of amyloid beta plaques in addition to neuronal loss and chronic neuroinflammation. Mouse models of AD, such as the hAPP-J20 mouse model, are valuable tools for investigating neuroprotective ...
Wright, Amanda
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Topological Regulation of Synaptic AMPA Receptor Expression by the RNA-Binding Protein CPEB3
Cell Reports, 2016 Synaptic receptors gate the neuronal response to incoming signals, but they are not homogeneously distributed on dendrites. A spatially defined receptor distribution can preferentially amplify certain synaptic inputs, resize receptive fields of neurons ...
Iaroslav Savtchouk +6 more
doaj +1 more source
Effect of GluA2 RNAi on motoneurons survival.
, 2013 A) Islet1/2-staining in the lumbar spinal cord of E11 chicken embryos. Only Islet1/2-positive neurons in the motoneurons pool were counted (circled area).
Sheryl L. White (296193) +4 more
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Role of GluA2-containing AMPARs in Oligodendrocyte Lineage Cells
Oligodendrocytes precursor cells (OPC), also called NG2 cells, proliferate or differentiate into myelin-producing oligodendrocytes throughout life. Myelination depends on neuronal activity. Although NG2 cells receive neuronal glutamatergic synaptic input
Faure, Vicky
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