FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation
Cell Reports, 2014 Translational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain.
Denise Cook +14 more
doaj +1 more source
GluA2 palmitoylation by SELENOK modulates AMPAR assembly and synaptic plasticity in Alzheimer's disease. [PDF]
Redox BiolSe is essential for central nervous system function, and its deficiency is strongly associated with cognitive decline, especially in neurodegenerative disorders such as Alzheimer's disease (AD). Although Se exerts its effects through selenoproteins, the molecular basis of its neuroprotective action remains unclear. Among selenoproteins, the endoplasmic
Peng J +10 more
europepmc +3 more sources
Effect of RCASBP(B)-RFP-GluA2 RNAi infection on chicken embryos.
, 2013 A–B) Expression of red fluorescence protein (RFP) transgene in the lumbar spinal cord of E6 (A) and E11 (B) chicken embryos following retroviral infection with an RCASBP(B)-RFP-GluA2 RNAi construct.
Sheryl L. White (296193) +4 more
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AMPARs contain GluA2 subunits.
, 2013 A: Example AMPAR responses at various holding potentials for cells with low (left) and high (right) rectification indices. Rectification indices indicate that AMPARs contain GluA2 subunits during the period of VCN-LSO input functional refinement (n = 21).
Xiwu Zhao (350040) +2 more
core +1 more source
eLife, 2017 Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in
Eleni Kougioumtzidou +7 more
doaj +1 more source
, 2012 The number and subunit composition of postsynaptic AMPA receptors (AMPARs) is a key determinant of synaptic transmission. The vast majority of AMPARs contain GluA2 subunit, which renders the channel impermeable to calcium. However, a small proportion are
Hanley, Jonathan G +2 more
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MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons [PDF]
, 2019 Homeostatic synaptic scaling is a negative feedback response to fluctuations in synaptic strength induced by developmental or learning-related processes, which maintains neuronal activity stable.
Silva, Mariline M +10 more
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Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
Nature Neuroscience, 2011 Upon retrieval, fear memories are rendered labile and prone to modification, necessitating a restabilization process of reconsolidation to persist further. This process is also crucial for modulating both strength and content of an existing memory and forms a promising therapeutic target for fear-related disorders.
Rao-Ruiz, P. +6 more
openaire +4 more sources
GluA2 is rapidly edited at the Q/R site during neural differentiation \(\textit {in vitro}\)
, 2015 The majority of AMPA receptors in the adult brain contain GluA2 subunits, which can be edited at the Q/R site, changing a glutamine to an arginine within the ion pore.
Fuhrmann, Gloria (Dr. rer. nat.) +4 more
core +1 more source
Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved [PDF]
, 2017 There is increasing evidence that extracellular cGMP modulates glutamatergic neurotransmission and some forms of learning. However, the underlying mechanisms remain unknown.
Vicente Felipo +11 more
core +1 more source