Results 41 to 50 of about 86,925 (261)
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
Desensitization dynamics of the AMPA receptor
Structure, 2023 To perform their physiological functions, amino methyl propionic acid receptors (AMPARs) cycle through active, resting, and desensitized states, and dysfunction in AMPAR activity is associated with various neurological disorders. Transitions among AMPAR functional states, however, are largely uncharacterized at atomic resolution and are difficult to ...
Jussi Aittoniemi +3 more
openaire +2 more sources
AMPA Receptors Bring On the Pain [PDF]
Neuron, 2004 The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Torsney, Carole, MacDermott, Amy B.
openaire +2 more sources
Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]
, 1997 Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C. +3 more
core +2 more sources
Neuroscience ResearchNMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors.
Qingchen Guo
doaj +1 more source
Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
core +2 more sources
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Frontiers in Molecular Neuroscience, 2021 Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb +7 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Parkinson’s disease (PD) is commonly accompanied with anxiety disorder, however, the mechanisms underlying PD-mediated anxiety remain elusive.
Jin Zhang +5 more
doaj +1 more source
Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
Neuroscience, 2009 Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Coombs, I.D., Cull-Candy, S.G.
openaire +2 more sources
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Shaikh, Sana A. +7 more
openaire +4 more sources