Results 11 to 20 of about 48,039 (217)

Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus

Frontiers in Cellular Neuroscience, 2021
Synaptic and axonal glutamatergic signaling to NG2 glia in white matter is critical for the cells’ differentiation and activity dependent myelination. However, in gray matter the impact of neuron-to-NG2 glia signaling is still elusive, because most of ...
Stefan Hardt, Dario Tascio, Stefan Passlick, Aline Timmermann, Ronald Jabs, Christian Steinhäuser, Gerald Seifert   +6 more
doaj   +1 more source

Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model

Life Science Alliance, 2022
RNA aptamers designed to block AMPA receptors effectively reduce progression of motor dysfunction, improve TDP-43 pathology, and prevent death of motor neurons in AR2 mice, a mouse model of sporadic ALS, without adverse effects.
Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Janet Lynch, Tatsushi Toda, Li Niu, Shin Kwak   +7 more
doaj   +1 more source

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model [PDF]

Brazilian Journal of Medical and Biological Research, 2020
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission.
Rong Li, Miaoqing He, Bing Wu, Peng Zhang, Qinbin Zhang, Yangmei Chen   +5 more
doaj   +1 more source

Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

eLife, 2022
At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1SS4+) and neurexin-3 (Nrxn3SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation.
Jinye Dai, Kif Liakath-Ali, Samantha Rose Golf, Thomas C Südhof   +3 more
doaj   +1 more source

Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation [PDF]

Annals of Rehabilitation Medicine, 2020
Objective To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model.
Dong Gyu Kwak, Dong Gyu Lee
doaj   +1 more source

Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation

Molecular Brain, 2021
Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened.
Boren Lin, Khaled Alganem, Sinead M. O’Donovan, Zhen Jin, FarzanehSadat Naghavi, Olivia A. Miller, Tyler C. Ortyl, Ye Chun Ruan, Robert E. McCullumsmith, Jianyang Du   +9 more
doaj   +1 more source

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Nature Communications, 2019
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang   +10 more
doaj   +1 more source

GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Frontiers in Molecular Neuroscience, 2012
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov, Rolf eSprengel, Peter H Seeburg   +2 more
doaj   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors. [PDF]

Glia
In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Allen TE, Peet G, Gomez Wulschner LE, Oh WC, Macklin WB.   +4 more
europepmc   +2 more sources