Posttranslational modifications of AMPA receptors in synaptic function and memory [PDF]
Cellular and Molecular Life SciencesAMPA receptors, members of the ionotropic glutamate receptor family, are the principal mediators of fast excitatory synaptic transmission in the brain, and their trafficking to and from synapses is critical for neuronal communication.
Cristina A. Muñoz de León-López +2 more
doaj +2 more sources
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Biomolecules, 2020 It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj +3 more sources
Regulating AMPA Receptors with Isoxazole-4-Carboxamide Derivatives: An Electrophysiological Study [PDF]
Journal of XenobioticsIsoxazole carboxamide derivatives are intriguing modulators of ionotropic glutamate receptors; more specifically, their prospective analgesic activities based on non-opioid pathways have sparked widespread research.
Mohammad Qneibi +6 more
doaj +2 more sources
Regulation of AMPA receptors in spinal nociception [PDF]
Molecular Pain, 2010 The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing +5 more
doaj +2 more sources
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain [PDF]
, 2013 Brain damage caused by an acute injury depends on the initial severity of the injury and the time elapsed after the injury. To determine whether these two variables activate common mechanisms, we compared the response of the rat medial septum to insult ...
Andrés, N. +6 more
core +7 more sources
Cells, 2022 The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi +3 more
doaj +1 more source
SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]
PLoS ONE, 2013 AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero +3 more
doaj +1 more source
Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
Cell Reports, 2023 Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan +10 more
doaj +1 more source
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases [PDF]
Cellular and Molecular NeurobiologyZafaruddin Khan
exaly +2 more sources
Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
doaj +1 more source