Results 1 to 10 of about 55,538 (273)

Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]

PLoS ONE, 2012
Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov, Tommi Möykkynen, Sarah K Coleman, Esa R Korpi, Kari Keinänen   +4 more
doaj   +2 more sources

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function [PDF]

Journal of Xenobiotics
Background: Fast excitatory transmission in the central nervous system is carried out by AMPA-type glutamate receptors. Neuronal hyperexcitability and epilepsy have been associated with the dysregulation of AMPA receptor function.
Sosana Bdir, İrfan Çapan, Mohammed Hawash, Süleyman Servi, Mohammad Qneibi   +4 more
doaj   +2 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

Cells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi, Safa’ Nassar, Sosana Bdir, Adel Hidmi   +3 more
doaj   +1 more source

SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]

PLoS ONE, 2013
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero, Sabine M Blankenship, Yun Shi, Roger A Nicoll   +3 more
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj   +1 more source

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]

Cellular and Molecular Life Sciences, 2019
To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the ...
Diane Bissen, Franziska Foss, Amparo Acker-Palmer   +2 more
openaire   +3 more sources

Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses

Frontiers in Synaptic Neuroscience, 2021
The amygdala plays a crucial role in attaching emotional significance to environmental cues. Its intercalated cell masses (ITC) are tight clusters of GABAergic neurons, which are distributed around the basolateral amygdala complex.
Anna Seewald, Sabine Schönherr, Heide Hörtnagl, Ingrid Ehrlich, Ingrid Ehrlich, Claudia Schmuckermair, Francesco Ferraguti   +6 more
doaj   +1 more source

Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus

Frontiers in Cellular Neuroscience, 2021
Synaptic and axonal glutamatergic signaling to NG2 glia in white matter is critical for the cells’ differentiation and activity dependent myelination. However, in gray matter the impact of neuron-to-NG2 glia signaling is still elusive, because most of ...
Stefan Hardt, Dario Tascio, Stefan Passlick, Aline Timmermann, Ronald Jabs, Christian Steinhäuser, Gerald Seifert   +6 more
doaj   +1 more source

Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model

Life Science Alliance, 2022
RNA aptamers designed to block AMPA receptors effectively reduce progression of motor dysfunction, improve TDP-43 pathology, and prevent death of motor neurons in AR2 mice, a mouse model of sporadic ALS, without adverse effects.
Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Janet Lynch, Tatsushi Toda, Li Niu, Shin Kwak   +7 more
doaj   +1 more source

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model [PDF]

Brazilian Journal of Medical and Biological Research, 2020
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission.
Rong Li, Miaoqing He, Bing Wu, Peng Zhang, Qinbin Zhang, Yangmei Chen   +5 more
doaj   +1 more source