Results 41 to 50 of about 55,538 (273)

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2021
Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb, Ali Harb, Nils Vogel, Ali Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann, Ralf Mohrmann   +7 more
doaj   +1 more source

Allosteric competition and inhibition in AMPA receptors

Nature Structural & Molecular Biology, 2023
Abstract Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through
W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey   +6 more
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Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
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Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]

, 2009
NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S., Hamilton, Nicola; id_orcid, Hamilton, N., Butt, Arthur, Hubbard, Paul, Butt, Arthur M., Hamilton, N, Hubbard, P., Butt, AM   +8 more
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Activation of AMPA Receptors in the Lateral Habenula Produces Anxiolytic Effects in a Rat Model of Parkinson’s Disease

Frontiers in Pharmacology, 2022
Background: Parkinson’s disease (PD) is commonly accompanied with anxiety disorder, however, the mechanisms underlying PD-mediated anxiety remain elusive.
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong   +5 more
doaj   +1 more source

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum

Neuroscience, 2009
Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Coombs, I.D., Cull-Candy, S.G.
openaire   +2 more sources

AMPA Receptors Bring On the Pain [PDF]

Neuron, 2004
The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Torsney, Carole, MacDermott, Amy B.
openaire   +2 more sources

Photoinactivation of Native AMPA Receptors Reveals Their Real-Time Trafficking [PDF]

, 2005
SummaryAMPA receptors mediate the majority of the fast excitatory transmission in the central nervous system. Much evidence suggests that the fast trafficking of AMPA receptors into and out of the postsynaptic membrane underlies changes in synaptic ...
Adesnik, Hillel, Pamela M England, Nicoll, Roger A., Roger A Nicoll, England, Pamela M., Hillel Adesnik   +5 more
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SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons

Neuroscience Research
Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj   +1 more source

Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors

, 2005
Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory.
Shimshek Derya R, Mack Volker, Derya R Shimshek, Peter H Seeburg, Sprengel, Rolf, Bus, T, Mihaljevic Andre, Bus, T., Sprengel, R, Kim Jinhyun, Schaefer, AT, Mihaljevic, A, Thorsten Bus (71683), Peter H Seeburg (71687), Shimshek, DR, Rolf Sprengel (71688), Schaefer, Andreas T., Seeburg, P., Jinhyun Kim, Andre Mihaljevic, Volker Mack (71686), Mihaljevic, André, Shimshek, Derya R., Derya R Shimshek (71682), Bus, Thorsten, Seeburg, Peter H., Rolf Sprengel, Kim, Jinhyun, Mack, V, Schaefer, A., Bus Thorsten, Schaefer Andreas T, Jinhyun Kim (71684), Kim, J, Seeburg Peter H, Seeburg, PH, Kim, J., Thorsten Bus, Andreas T Schaefer, Shimshek, D., Mack, Volker, Sprengel Rolf, Mack, V., Andre Mihaljevic (71685), Volker Mack, Mihaljevic, A., Sprengel, R., Andreas T Schaefer (71689)   +47 more
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