Results 31 to 40 of about 86,367 (206)

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

eLife, 2018
Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj   +1 more source

Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013
The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate.
V. N. Ochkolyas, A. F. Gurchin, A. A. Skoromets, A. V. Kostyukevich   +3 more
doaj   +1 more source

Ion channel gradients in the apical tuft region of CA1 pyramidal neurons. [PDF]

PLoS ONE, 2012
Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally important for synaptic integration and plasticity. In the hippocampal region CA1, somato-dendritic gradients of AMPA receptors and the hyperpolarization-activated
Katie C Bittner, Bertalan K Andrasfalvy, Jeffrey C Magee   +2 more
doaj   +1 more source

Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors

Frontiers in Cell and Developmental Biology, 2023
Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl ...
Marina N. Vukolova, Laura Y. Yen, Laura Y. Yen, Margarita I. Khmyz, Alexander I. Sobolevsky, Maria V. Yelshanskaya   +5 more
doaj   +1 more source

Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]

, 2003
Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
core   +2 more sources

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model

Neuroscience Research
NMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors.
Qingchen Guo
doaj   +1 more source

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2021
Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb, Ali Harb, Nils Vogel, Ali Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann, Ralf Mohrmann   +7 more
doaj   +1 more source

Activation of AMPA Receptors in the Lateral Habenula Produces Anxiolytic Effects in a Rat Model of Parkinson’s Disease

Frontiers in Pharmacology, 2022
Background: Parkinson’s disease (PD) is commonly accompanied with anxiety disorder, however, the mechanisms underlying PD-mediated anxiety remain elusive.
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong   +5 more
doaj   +1 more source