Results 41 to 50 of about 14,818 (181)

Aromatic Diboronic Acids as Effective KPC/AmpC Inhibitors

Molecules, 2023
Over 30 compounds, including para-, meta-, and ortho-phenylenediboronic acids, ortho-substituted phenylboronic acids, benzenetriboronic acids, di- and triboronated thiophenes, and pyridine derivatives were investigated as potential β-lactamase inhibitors.
Joanna Krajewska, Piotr Chyży, Krzysztof Durka, Patrycja Wińska, Krystiana A. Krzyśko, Sergiusz Luliński, Agnieszka E. Laudy   +6 more
openaire   +3 more sources

AMPc - Sinalização intracelular: um software educacional [PDF]

Química Nova, 2004
Chemicals binding to membrane receptors may induce events within the cell changing its behavior. Since these events are simultaneous and hard to be understood by students, we developed a computational model to dynamically and visually explore the cAMP signaling system to facilitate its understanding.
Yokaichiya, Daniela K., Fraceto, Leonardo F., Miranda, Márcio A., Galembeck, Eduardo, Torres, Bayardo B.   +4 more
openaire   +4 more sources

Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Although prophylactic broad‐spectrum antibiotics can reduce postoperative complications after pancreaticoduodenectomy (PD), the optimal regimen remains uncertain. This study evaluated the impact of prophylactic cefepime (CFPM) on surgical site infection (SSI) and severe morbidity after PD with preoperative biliary drainage.
Genki Watanabe, Akihiro Murata, Yu Kasamatsu, Atsushi Ishihara, Daisuke Nagashima, Tetsuzo Tashima, Shintaro Kodai, Akishige Kanazawa, Sadatoshi Shimizu   +8 more
wiley   +1 more source

Occurrence and detection of AmpC β-lactamases among Enterobacteriaceae isolates from patients at Ain Shams University Hospital

Egyptian Journal of Medical Human Genetics, 2015
Background: AmpC β-lactamases are often plasmid mediated that hydrolyze all β-lactam antibiotics except cefepime and carbapenems. Aim of the study: We aimed to evaluate the presence of AmpC β-lactamase among Enterobacteriaceae isolates separated from ...
Soha A. El-Hady, Lamiaa A. Adel
doaj   +1 more source

Prevalence study of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking inducible ampC from Saudi hospitals

Journal of Medical Microbiology, 2017
Enterobacteriaceae encoding plasmid-mediated AmpC (pAmpC) β-lactamases confer resistance to the third generation cephalosporins. pAmpC association with extended spectrum β-lactamases (ESBLs), plasmid-mediated quinolone resistance (PMQR) and aminoglycoside modifying enzymes (AMEs) is well documented. There are limited data regarding the epidemiology and
Baha, Abdalhamid, Samar, Albunayan, Alaa, Shaikh, Nasreldin, Elhadi, Reem, Aljindan   +4 more
openaire   +2 more sources

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

iMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo, Xiyang Dong, Jia‑Ling Li, Ji‐Cheng Yao, Ziqi Peng, Qi Li, Zi‐Wen Yang, Yang Yuan, Wen‑Jun Li, Pandeng Wang   +9 more
wiley   +1 more source

Incidence of Urinary Tract Infection After Combined Cystoscopy and Urodynamic Testing: A Prospective Cohort Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To evaluate the incidence of urinary tract infection (UTI) after combined cystoscopy and urodynamic testing. Methods A prospective analytical cohort study was conducted including adult patients undergoing cystoscopy, urodynamic testing, or both procedures during the same session at a quaternary referral center between May 1, 2023 ...
Camilo Andres Torres Sandoval, María Juliana Arcila, Andrés Duarte Osorio, Juan Guillermo Cataño, Sebastian Peña Rodriguez   +4 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Prevalence of Extended Spectrum β-Lactamase, Metallo β-Lactamase, and AmpC β-Lactamase among Gram Negative Bacilli Recovered from Burn Wound Infection

RUHS Journal of Health Sciences, 2023
Introduction: Infections are the major cause of morbidity and mortality in burn patients. The ESBL, MBL and AmpC are the major mediators of antimicrobial resistance in gram negative bacteria. Early detection of ESBL, MBL and AmpC β -lactamases is crucial
Kusum Lata Lodha, Seema Surana
doaj   +1 more source

AmpC β-lactamase induction by avibactam and relebactam [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Diazabicyclooctanes, e.g. avibactam and relebactam, are a new class of β-lactamase inhibitors. Their spectrum includes AmpC enzymes, but it is important to understand whether they also induce these enzymes.Levels of ampC mRNA were measured by RT-PCR during 4 h of exposure of Enterobacter cloacae, Citrobacter freundii and Pseudomonas aeruginosa (n = 5 ...
Livermore, David M, Jamrozy, Dorota, Mushtaq, Shazad, Nichols, Wright W, Young, Katherine, Woodford, Neil   +5 more
openaire   +4 more sources