A C-Glycosidation Approach to the Central Core of Amphidinol 3: Synthesis of the C39−C52 Fragment
, 2016 A concise route to an advance precursor (3) of the central core of amphidinol 3, a natural occurring polyketide, has been developed by applying a reductive lithiation as key step.
Javier de Vicente (1534099) +2 more
core +1 more source
Screening of several Amphidinium species and strains for amphidinols and related secondary metabolites [PDF]
, 2021 The presented thesis successfully provided the missing knowledge about the tox-in profiles of every received sample strain by using the selected reaction monitor-ing method in an UHPLC-MS/MS instrument.
Weber, Jannik
core
, 2016 A synthesis of the C(1)−C(25) fragment of amphidinol 3 is described. The synthesis features two applications of double allylboration reaction methodology for the highly stereoselective synthesis of 1,5-diol units in the C(1)−C(15 ...
Eric M. Flamme (2662519) +1 more
core +1 more source
The Polyol Domain of Amphidinol 3. A Stereoselective Synthesis of the Entire C(1)−C(30) Sector
, 2016 The richly oxygenated C(1)−C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target.
Leo A. Paquette (2352241) +1 more
core +1 more source
Algal amphidinols, an alternative to sulfites in the fight against Brettanomyces bruxellensis
LWTThis study evaluated the biocidal activity of a microalgal extract from Amphidinium carterae under oenological conditions to limit Brettanomyces bruxellensis development in red wines over 150 days. Viable and culturable cell concentrations were analyzed during this period.
Abry, Chloé +5 more
openaire +1 more source
Direct and Stereospecific Interaction of Amphidinol 3 with Sterol in Lipid Bilayers
, 2016 Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. Although AM3 permeabilizes phospholipid membranes only in the presence of sterol, the detailed molecular basis by ...
Nobuaki Matsumori (1450381) +3 more
core +1 more source
Stereoselective Synthesis of the C31−C40/C43−C52 Unit of Amphidinol 3
, 2016 A concise synthesis of a tetrahydropyran ring system corresponding to the C31−C40 and C43−C52 units of amphidinol 3 is described. Successive chemoselective reactions, i.e., cross-metathesis to differentiate the iodoolefin from the terminal olefin and ...
Tohru Oishi (1581409) +2 more
core +1 more source
Diastereoselective synthesis of syn-1,3-polyols and studies towards the C1-C31 and C32-C52 fragments of amphidinol 3 [PDF]
Diastereoselective Synthesis of syn-1,3-Polyols The stereoselective construction of polyacetate 1,3-diols has attracted considerable attention due to the ubiquity of this motif in complex biologically active polyene macrolides (amphotericin B, RK-397 ...
Grisin, Aleksandr
core +1 more source
Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review. [PDF]
Molecules, 2023 Mushtaq A +8 more
europepmc +1 more source
Unlocking the Health Potential of Microalgae as Sustainable Sources of Bioactive Compounds. [PDF]
Int J Mol Sci, 2021 Saide A +3 more
europepmc +1 more source