Results 21 to 30 of about 276 (135)
Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge
International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011 Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL.
Agus Trianto +5 more
wiley +1 more source
Roles of integral protein in membrane permeabilization by amphidinols
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008 Amphidinols (AMs) are a group of dinoflagellate metabolites with potent antifungal activity. As is the case with polyene macrolide antibiotics, the mode of action of AMs is accounted for by direct interaction with lipid bilayers, which leads to formation of pores or lesions in biomembranes.
Morsy, Nagy +6 more
openaire +2 more sources
Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3
Angewandte Chemie, 2018 AbstractAmphidinol 3 (AM3) is a marine natural product produced by the dinoflagellate Amphidinium klebsii. Although the absolute configuration of AM3 was determined in 1999 by extensive NMR analysis and degradation of the natural product, it was a daunting task because of the presence of numerous stereogenic centers on the acyclic carbon chain and the ...
Yuma Wakamiya +6 more
openaire +3 more sources
, 2016 Absolute Configuration of Amphidinol 3, the First Complete Structure Determination from Amphidinol Homologues: Application of a New Configuration Analysis Based on Carbon−Hydrogen Spin-Coupling ...
Nobuaki Matsumori (1450381) +4 more
core +1 more source
, 2004 Amphidinols, which are polyene-polyhydroxy metabolites produced by the marine dinoflagellate Amphidinium klebsii, possess potent antifungal and hemolytic activities.
Shigeru Matsuoka +7 more
core +1 more source
, 2016 An advanced intermediate for the synthesis of amphidinol 3 has been prepared. A cross-metathesis reaction was used to couple the C1−C12 and C13−C26 segments.
Javier de Vicente (1534099) +2 more
core +1 more source
Synthesis of the Bis-tetrahydropyran Core of Amphidinol 3
, 2016 A convergent synthesis of the C31−C52 bis-tetrahydropyran core of the natural product amphidinol 3 is reported. A common intermediate was synthesized from d-tartaric acid utilizing an asymmetric glycolate alkylation/ring-closing metathesis sequence to ...
Michael T. Crimmins (1317639) +2 more
core +2 more sources
, 2016 Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae.
Genoveffa Nuzzo (1773460) +3 more
core +1 more source
Structure and Biosynthesis of Amphidinol 17, a Hemolytic Compound from Amphidinium carterae
, 2016 Amphidinol 17 (AM17; 1), a novel amphidinol, has been isolated from a Bahamas strain of Amphidinium carterae. This new congener contains the signature hairpin region and a Δ6 polyene arm, whereas the polyol arm is distinct from those of other amphidinols.
Carmelo Tomas (2127943) +4 more
core +1 more source
, 2014 Two new polyketides of the amphidinol family, amphidinol 18 (wAM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae.
Sardo Angela +3 more
core +1 more source