Results 11 to 20 of about 175 (106)
LC-MS/MS Detection of Karlotoxins Reveals New Variants in Strains of the Marine Dinoflagellate Karlodinium veneficum from the Ebro Delta (NW Mediterranean) [PDF]
Marine Drugs, 2017 A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the detection and quantitation of karlotoxins in the selected reaction monitoring (SRM) mode. This novel method was based upon the analysis of purified karlotoxins (KcTx-
Bernd Krock +11 more
doaj +2 more sources
First Identification of Amphidinols from Mexican Strains and New Analogs. [PDF]
Toxins (Basel), 2023 The genus Amphidinium has been the subject of recent attention due to the production of polyketide metabolites. Some of these compounds have shown significant bioactivities and could be related to species interactions in the natural benthic microenvironment. Among these compounds, amphidinols (AMs) are suspected to be related to fish kills and probably
Durán-Riveroll LM, Weber J, Krock B.
europepmc +6 more sources
Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III). [PDF]
Int J Mol Sci, 2021 Microalgae have received growing interest for their capacity to produce bioactive metabolites. This study aimed at characterising the antimicrobial potential of the marine dinoflagellate Amphidinium carterae strain LACW11, isolated from the west of Ireland.
Barone ME +6 more
europepmc +4 more sources
Synthesis of the bis-tetrahydropyran core of amphidinol 3. [PDF]
Org Lett, 2010 A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 is reported. A common intermediate was synthesized from D-tartaric acid utilizing an asymmetric glycolate alkylation/ring-closing metathesis sequence to construct the THP rings.
Crimmins MT, Martin TJ, Martinot TA.
europepmc +5 more sources
Toxins, 2022 The two main methods for partitioning crude methanolic extract from Amphidinium carterae biomass were compared. The objective was to obtain three enriched fractions containing amphidinols (APDs), carotenoids, and fatty acids.
Mercedes López-Rodríguez +8 more
doaj +1 more source
Brown Allylation: Application to the Synthesis of Natural Products
European Journal of Organic Chemistry, Volume 2021, Issue 22, Page 3214-3222, June 14, 2021., 2021 The Brown allylation is a well‐known efficient tool for the synthesis of chiral homoallylic alcohols. Here we address the way in which it can be applied to furnish valuable intermediates and versatile building blocks in the synthesis of complex natural products.
Zlata Boiarska +3 more
wiley +1 more source
LC-MS/MS Method Development for the Discovery and Identification of Amphidinols Produced by Amphidinium. [PDF]
Mar Drugs, 2020 Amphidinols are polyketides produced by dinoflagellates suspected of causing fish kills. Here, we demonstrate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the identification and quantification of amphidinols (AM). Novel AM were detected by neutral loss (NL) scan and then quantified together with known AM by selection reaction ...
Wellkamp M +5 more
europepmc +7 more sources
Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge
International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011 Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL.
Agus Trianto +5 more
wiley +1 more source
Roles of integral protein in membrane permeabilization by amphidinols
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008 Amphidinols (AMs) are a group of dinoflagellate metabolites with potent antifungal activity. As is the case with polyene macrolide antibiotics, the mode of action of AMs is accounted for by direct interaction with lipid bilayers, which leads to formation of pores or lesions in biomembranes.
Morsy, Nagy +6 more
openaire +2 more sources
Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3. [PDF]
Sci Rep, 2017 AbstractAmphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in
Iwamoto M +5 more
europepmc +4 more sources