Isolation and Structural Elucidation of New Amphidinol Analogues from Amphidinium carterae Cultivated in a Pilot-Scale Photobioreactor [PDF]
Marine Drugs, 2021 The demand for valuable products from dinoflagellate biotechnology has increased remarkably in recent years due to their many prospective applications.
Adrián Morales-Amador +6 more
doaj +3 more sources
Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae [PDF]
Marine Drugs, 2019 Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats.
Kevin A. Martínez +11 more
doaj +7 more sources
Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation [PDF]
Biochemistry and Biophysics Reports, 2021 Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds
Masanao Kinoshita, Nobuaki Matsumori
exaly +4 more sources
Effect of Nitrogen, Phosphorous, and Light Colimitation on Amphidinol Production and Growth in the Marine Dinoflagellate Microalga Amphidinium carterae [PDF]
Toxins, 2022 The marine dinoflagellate microalga Amphidinium carterae is a source of amphidinols, a fascinating group of polyketide metabolites potentially useful in drug design.
Alejandro Molina-Miras +5 more
doaj +4 more sources
High Inter- and Intraspecific Variability in Amphidinol Content and Toxicity of Amphidinium Strains [PDF]
Marine DrugsAmphidinols (AM) are a diverse group of bioactive polyketides produced by dinoflagellates of the genus Amphidinium, known for their hemolytic, antifungal, and cytotoxic activities.
Catharina Alves-de-Souza +6 more
doaj +4 more sources
The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae [PDF]
Marine Drugs, 2017 Two new members of the amphidinol family, amphidinol A (1) and its 7-sulfate derivative amphidinol B (2), were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples (Italy), and chemically identified by spectroscopic and ...
Adele Cutignano +3 more
doaj +4 more sources
Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III). [PDF]
Int J Mol Sci, 2021 Microalgae have received growing interest for their capacity to produce bioactive metabolites. This study aimed at characterising the antimicrobial potential of the marine dinoflagellate Amphidinium carterae strain LACW11, isolated from the west of Ireland.
Barone ME +6 more
europepmc +5 more sources
Acute Toxicity of the Dinoflagellate Amphidinium carterae on Early Life Stages of Zebrafish (Danio rerio) [PDF]
Toxics, 2023 Dinoflagellates of the genus Amphidinium can produce a variety of polyketides, such as amphidinols (AMs), amphidinoketides, and amphidinin, that have hemolytic, cytotoxic, and fish mortality properties.
Xiao Yang +4 more
doaj +2 more sources
Investigating A Multi-Domain Polyketide Synthase in Amphidinium carterae [PDF]
Marine Drugs, 2023 Dinoflagellates are unicellular organisms that are implicated in harmful algal blooms (HABs) caused by potent toxins that are produced through polyketide synthase (PKS) pathways.
Saddef Haq +6 more
doaj +2 more sources
First Identification of Amphidinols from Mexican Strains and New Analogs. [PDF]
Toxins (Basel), 2023 The genus Amphidinium has been the subject of recent attention due to the production of polyketide metabolites. Some of these compounds have shown significant bioactivities and could be related to species interactions in the natural benthic microenvironment. Among these compounds, amphidinols (AMs) are suspected to be related to fish kills and probably
Durán-Riveroll LM, Weber J, Krock B.
europepmc +6 more sources