Isolation and Structural Elucidation of New Amphidinol Analogues from Amphidinium carterae Cultivated in a Pilot-Scale Photobioreactor [PDF]
Marine Drugs, 2021 The demand for valuable products from dinoflagellate biotechnology has increased remarkably in recent years due to their many prospective applications.
Adrián Morales-Amador +6 more
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Acute Toxicity of the Dinoflagellate Amphidinium carterae on Early Life Stages of Zebrafish (Danio rerio) [PDF]
Toxics, 2023 Dinoflagellates of the genus Amphidinium can produce a variety of polyketides, such as amphidinols (AMs), amphidinoketides, and amphidinin, that have hemolytic, cytotoxic, and fish mortality properties.
Xiao Yang +4 more
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Investigating A Multi-Domain Polyketide Synthase in Amphidinium carterae [PDF]
Marine Drugs, 2023 Dinoflagellates are unicellular organisms that are implicated in harmful algal blooms (HABs) caused by potent toxins that are produced through polyketide synthase (PKS) pathways.
Saddef Haq +6 more
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Effect of Nitrogen, Phosphorous, and Light Colimitation on Amphidinol Production and Growth in the Marine Dinoflagellate Microalga Amphidinium carterae [PDF]
Toxins, 2022 The marine dinoflagellate microalga Amphidinium carterae is a source of amphidinols, a fascinating group of polyketide metabolites potentially useful in drug design.
Alejandro Molina-Miras +5 more
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Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation [PDF]
Biochemistry and Biophysics Reports, 2021 Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds
Manami Hieda +3 more
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Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae [PDF]
Marine Drugs, 2019 Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats.
Kevin A. Martínez +11 more
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The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae [PDF]
Marine Drugs, 2017 Two new members of the amphidinol family, amphidinol A (1) and its 7-sulfate derivative amphidinol B (2), were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples (Italy), and chemically identified by spectroscopic and ...
Adele Cutignano +3 more
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Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesStructural studies of natural products have been a driving force in the development of organic chemistry throughout its long history, especially in the early years. Recently, structure determination based on new concepts has also gained momentum. In this
Michio MURATA +2 more
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High Inter- and Intraspecific Variability in Amphidinol Content and Toxicity of Amphidinium Strains [PDF]
Marine DrugsAmphidinols (AM) are a diverse group of bioactive polyketides produced by dinoflagellates of the genus Amphidinium, known for their hemolytic, antifungal, and cytotoxic activities.
Catharina Alves-de-Souza +6 more
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HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger [PDF]
Marine Drugs, 2017 Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation.
Aaron John Christian Andersen +7 more
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