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Synthetic Approach toward Structure Confirmation of Amphidinol 3
Synthetic Approach toward Structure Confirmation of Amphidinol 3openaire
Structure-based Study on Mode of Action of Dinoflagellate Metabolites, Amphidinols
Structure-based Study on Mode of Action of Dinoflagellate Metabolites, Amphidinolsopenaire
Structure Elucidation and Mode of Action of Amphidinol Homologues from Marine Dinoflagellate
Structure Elucidation and Mode of Action of Amphidinol Homologues from Marine Dinoflagellateopenaire
High Inter- and Intraspecific Variability in Amphidinol Content and Toxicity of Amphidinium Strains
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Roles of integral protein in membrane permeabilization by amphidinols
Biochimica Et Biophysica Acta - Biomembranes, 2008 Amphidinols (AMs) are a group of dinoflagellate metabolites with potent antifungal activity. As is the case with polyene macrolide antibiotics, the mode of action of AMs is accounted for by direct interaction with lipid bilayers, which leads to formation of pores or lesions in biomembranes.
Keiichi Konoki +2 more
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Effects of lipid constituents on membrane-permeabilizing activity of amphidinols
Bioorganic and Medicinal Chemistry, 2008Amphidinols (AMs) are a new class of polyhydroxyl polyene compounds with potent antifungal activity. Membrane-permeabilizing activities of AM2, AM3, and AM6 were examined using fluorescent-dye leakage experiments with various phosphatidylcholines (PCs) and sterols. All the AMs tested showed the potent activity to cholesterol-containing liposomes.
Keiichi Konoki +2 more
exaly +3 more sources
Efficient Syntheses of the Polyene Fragments Present in Amphidinols
Synlett, 2007The C53-C67 and C53-C65 polyene fragments of amphidinols have been synthesized in an efficient and convergent fashion from sorbic acid in good overall yields (30-31%) by employing a chemoselective cross-metathesis of a Weinreb amide and a Julia-Kocienski olefination as the key steps.
Janine Cossy
exaly +2 more sources
Journal of the American Chemical Society, 2020
Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce natural product due to the presence of numerous stereogenic centers on the acyclic carbon chain.
Yuma Wakamiya +3 more
openaire +2 more sources
Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce natural product due to the presence of numerous stereogenic centers on the acyclic carbon chain.
Yuma Wakamiya +3 more
openaire +2 more sources
Synthesis of the C31—C67 Fragment of Amphidinol 3.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Javier, de Vicente +2 more
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Confirmation of the Absolute Configuration at C45 of Amphidinol 3
Journal of Natural Products, 2012Amphidinol 3 (AM3), a membrane-active agent isolated from the dinoflagellate Amphidinium klebsii, consists of a long carbon chain containing 25 stereogenic centers. Although the absolute configuration of AM3 was determined by extensive NMR analysis and degradation of the natural product, the partial structure corresponding to the tetrahydropyran ring ...
Yoshiyuki, Manabe +4 more
openaire +2 more sources