Results 171 to 180 of about 381,413 (281)

Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery

Small, EarlyView.
A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee, Moo Chang Park, Sung Chan Choi, Jieun Kim, Joo‐young Kim, Jiah Lee, Hyun Jin Kim, Kyobum Kim, Yongju Kim, Woo‐jin Jeong   +9 more
wiley   +1 more source

ROS-Responsive Methionine-Containing Amphiphilic Peptides Impart Enzyme-Triggered Phase Transition and Antioxidant Cell Protection. [PDF]

Biomacromolecules
Hara Y, Yoshizawa K, Yaguchi A, Hiramatsu H, Uchida N, Muraoka T.   +5 more
europepmc   +1 more source

Interface‐Directed Self‐Assembly of Thermoresponsive Block Copolymers for Tunable Interfacial Nanostructures

Small, EarlyView.
Surface pressure and temperature direct the assembly of P(NIPAM‐b‐AEMA) at the air‐water interface, transforming continuous films into tunable micellar nanodomains. The thermoresponsive P(NIPAM) block enables temperature‐controlled changes in domain size and order.
Miriam Peña‐Figueroa, Armando Maestro, Ester Verde‐Sesto, Alberto Alvarez‐Fernandez   +3 more
wiley   +1 more source

Host-guest binding between cucurbit[8]uril and amphiphilic peptides achieved tunable supramolecular aggregates for cancer diagnosis. [PDF]

Chem Sci
Niu J, Yu J, Wu X, Zhang YM, Chen Y, Yu Z, Liu Y.   +6 more
europepmc   +1 more source

Self‐Assembling Gemini‐Type Amphiphiles From Helix‐Loop‐Helix Peptides

Small, EarlyView.
Peptide particles are formed through self‐assembly of amphiphilic helix‐loop‐helix peptides. Depending on the preparation method, two different particle morphologies can be obtained: nanospheres or nanodiscs with α‐helical or β‐sheet structure of the monomers, respectively.
Thomas Heim, Charlotte Helm, Morten Mosbach, Ernest Ronald Curticean, Vanessa Reusche, Irene Wacker, Rasmus R. Schröder, Franziska Thomas   +7 more
wiley   +1 more source

One‐Pot Fabrication of Pentapeptide Bio‐Aerogel via Direct Alcogelation

Small, EarlyView.
A minimal tachykinin‐inspired pentapeptide (TC‐1) self‐assembles in water and ethanol to form robust gels that can be dried in one pot to ultra‐porous aerogels using supercritical carbon dioxide. Solvent choice programs nanoscale packing and bulk mechanics producing lightweight monoliths with high porosity for biomaterials applications, verified by ...
Brody McDonald, Durga Dharmadana, Nevena Todorova, Boyin Liu, Shuaiyu Jiang, Ewan W. Blanch, Céline Valéry   +6 more
wiley   +1 more source

Reverse Micelles: The Gateway for Oral (Poly)Peptide Delivery

Small, EarlyView.
RM achieve superior oral peptide delivery through high loading capacity, strong lipophilicity, and a low‐hydration microenvironment that protects against enzymatic degradation. Meanwhile, dRM provides favorable permeation‐enhancing interactions and a consistent safety profile, collectively driving enhanced oral performance.
Marlene Ramona Schmidt, Melanie Lena Ebert, Andreas Bernkop‐Schnürch   +2 more
wiley   +1 more source

Bidirectional Plant‐Microneedle Responses to Guide Biomaterial Design

Small, EarlyView.
We examine bidirectional interactions between plants and polymeric microneedles to develop effective compound delivery strategies. Material chemistry and architecture determine stability in the plant environment, cargo–matrix interactions, and the magnitude and duration of the plant response. Plant microneedles should therefore be designed as a coupled
Sally Shuxian Koh, Meng Li, Kasey Goh, Yunteng Cao, Yangyang Han, Raju Cheerlavancha, Liang Cui, Benedetto Marelli, Daisuke Urano   +8 more
wiley   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source