Results 121 to 130 of about 13,097,347 (378)

A Randomized, Blinded, Multicenter Trial of Lipid-Associated Amphotericin B Alone versus in Combination with an Antibody-Based Inhibitor of Heat Shock Protein 90 in Patients with Invasive Candidiasis [PDF]

, 2017
Background. Mycograb (NeuTec Pharma) is a human recombinant monoclonal antibody against heat shock protein 90 that, in laboratory studies, was revealed to have synergy with amphotericin B against a broad spectrum of Candida species. Methods.
Aoun, Mickael, Burnie, James, Drgona, Lubos, Garbino, Jorge, Jacobs, Frédérique, Malbrain, Manu, Masterson, Gary, Matthews, Ruth, Pachl, Jan, Spronk, Peter, Svoboda, Petr, Takala, Jukka, van der Hoven, Ben, Vandewoude, Koenraad   +13 more
core  

Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).

, 2013
A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20-50%.
Brocchini, Stephen, Croft, Simon L, Les, Karolina A, Mohamed-Ahmed, Abeer HA, Seifert, Karin   +4 more
core   +1 more source

Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence. [PDF]

, 2016
Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Stewart, Ethan R, Thompson, George R
core   +3 more sources

Delivery strategies of amphotericin B for invasive fungal infections

Acta Pharmaceutica Sinica B, 2021
Xiaochun Wang, I. Mohammad, Lifang Fan, Zongmin Zhao, M. Nurunnabi, Marwa A. Sallam, Jun Wu, Zhongjian Chen, Lifang Yin, Wei He   +9 more
semanticscholar   +1 more source

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

PLoS Biology, 2013
The rarity of clinical drug resistance to the antifungal amphotericin B is explained by the extreme costs that resistance mutations impose upon stress responses and virulence factors.
B. Vincent, A. Lancaster, Ruth Scherz-Shouval, L. Whitesell, S. Lindquist   +4 more
semanticscholar   +1 more source

Physicochemical and Biological Properties of ZnO‐Incorporated Natural Rubber for Potential Wound Dressing Applications

Journal of Applied Polymer Science, EarlyView.
ABSTRACT Antibiotic resistance has driven the search for effective alternatives in wound dressing development to reduce infection risk. In this context, incorporating metal particles into natural polymers has gained attention due to the synergistic properties of this combination.
Renata Leme, Bruna V. Quevedo, Jessica Asami, Thais Alves, Marco V. Chaud, Eliana Aparecida de Rezende Duek, Daniel Komatsu   +6 more
wiley   +1 more source

Using single-dose liposomal amphotericin B for cryptococcal meningitis induction therapy: nurse pearls and practical perspectives [version 1; peer review: 2 approved]

Wellcome Open Research
Background In Uganda where the burden of HIV-associated cryptococcal meningitis is high, conventional amphotericin B deoxycholate has been standard to manage patients with cryptococcal meningitis in research settings.
Richard Kwizera, Cynthia Ahimbisibwe, Jane Frances Ndyetukira, David B. Meya, Carol Namujju   +4 more
doaj  

Fungal infections of the central nervous system: A review of fungal pathogens and treatment [PDF]

, 2007
Multiple factors influence the outcome of fungal infection of the central nervous system (CNS). The host and the pathogen in concert with drug delivery across the blood-brain barrier and drug activity are key factors in outcome.
Dancer, C., Redmond, A., Woods, M. L.
core   +1 more source

Comparison of caspofungin and amphotericin B for invasive candidiasis.

New England Journal of Medicine, 2002
BACKGROUND Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis.
Jorge Mora-Duarte, R. Betts, C. Rotstein, A. Colombo, Luis Thompson-Moya, Juanita M. Smietana, R. Lupinacci, C. Sable, N. Kartsonis, J. Perfect   +9 more
semanticscholar   +1 more source

Liposomal Amphotericin B

Nippon Ishinkin Gakkai Zasshi, 2005
Liposomal amphotericin B (AmBisome) is a DDS (drug delivery system) formulation of amphotericin B (AMPH-B), and has been developed in an attempt to reduce the toxicity of AMPH-B while retaining its therapeutic efficacy. AMPH-B has been the "gold standard" of antifungal therapy over the past four decades.
openaire   +4 more sources