Results 11 to 20 of about 95,889 (290)

Identifying genetic variants associated with amphotericin B (AMB) resistance in Aspergillus fumigatus via k-mer-based GWAS

Frontiers in Genetics, 2023
Aspergillus fumigatus is one of the most common pathogenic fungi, which results in high morbidity and mortality in immunocompromised patients. Amphotericin B (AMB) is used as the core drug for the treatment of triazole-resistant A. fumigatus.
Meng-Meng Chen, Meng-Meng Chen, Guo-Hui Shi, Yi Dai, Yi Dai, Wen-Xia Fang, Qi Wu, Qi Wu   +7 more
doaj   +1 more source

Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. [PDF]

PLoS ONE, 2014
The polyene antifungal agent Amphotericin B exhibits potent and broad spectrum fungicidal activity. However, high nephrotoxicity can hinder its administration in resource poor settings.
Dithi Banerjee, Lauren Burkard, John C Panepinto   +2 more
doaj   +1 more source

Comparative pharmacokinetics of amphotericin B after single- and multiple-dose administration of G-ABCD and conventional amphotericin B deoxycholate to rats

Journal of Global Antimicrobial Resistance, 2020
Objective: G-ABCD is a biosimilar product of amphotericin B colloidal dispersion (ABCD). This study was designed to systematically examine the plasma pharmacokinetics (PK) and tissue distribution of G-ABCD in rats, using amphotericin B deoxycholate (DAmB)
Huanhuan Qi, Xueyuan Zhang, Hao Feng, Yating Xiong, Yuancheng Chen, Jing Zhang, Chunlei Li   +6 more
doaj   +1 more source

Lipase-Responsive Amphotericin B Loaded PCL Nanoparticles for Antifungal Therapies

Nanomaterials, 2022
Amphotericin B is an antifungal drug used for the treatment of invasive fungal infections. However, its clinical use is limited due to its serious side effects, such as renal and cardiovascular toxicity.
Evelyn Osehontue Uroro, Richard Bright, Andrew Hayles, Krasimir Vasilev   +3 more
doaj   +1 more source

Taming Amphotericin B [PDF]

Bioconjugate Chemistry, 2015
A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine
Vaclav Janout, Damien Thévenin, Yuming Yu, Wiley A. Schell, Steven L. Regen, John R. Perfect   +5 more
openaire   +2 more sources

Liposomal amphotericin B—the present

Journal of Antimicrobial Chemotherapy, 2022
AbstractMost invasive fungal infections are opportunistic in nature but the epidemiology is constantly changing, with new risk groups being identified. Neutropenia is a classical risk factor for fungal infections, while critically ill patients in the ICU are now increasingly at risk of yeast and mould infections.
Maertens, J., Pagano, L., Azoulay, E., Warris, A.   +3 more
openaire   +4 more sources

Therapeutic Drug Monitoring of Amphotericin-B in Plasma and Peritoneal Fluid of Pediatric Patients after Liver Transplantation: A Case Series

Antibiotics, 2022
Fungal infections represent a serious complication during the post-liver transplantation period. Abdominal infections can occur following pre-existing colonization, surgical procedures, and permanence of abdominal tubes.
Francesca Tortora, Luigi Dei Giudici, Raffaele Simeoli, Fabrizio Chiusolo, Sara Cairoli, Paola Bernaschi, Roberto Bianchi, Sergio Giuseppe Picardo, Carlo Dionisi Vici, Bianca Maria Goffredo   +9 more
doaj   +1 more source

Itraconazole or Amphotericin B for Talaromycosis [PDF]

New England Journal of Medicine, 2017
Item does not contain ...
Bruggemann, R.J.M., Bruggemann, R.J.M., van de Veerdonk, F.L., Verweij, P.E.   +3 more
openaire   +6 more sources

Comparative efficacy and tolerability of amphotericin B lipid complex and liposomal amphotericin B in the treatment of invasive fungal infections in patients with hematological malignancies: literature review

Онкогематология, 2014
An overview of the literature data concerning the comparison of toxicity, efficacy and cost of amphotericin B lipid complex and liposomal amphotericin B, as well as their comparison with amphotericin B deoxycholate are provided.
N. V. Dmitrieva, I. N. Petukhova
doaj   +3 more sources

Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity

Brazilian Journal of Biology, 2018
Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug.
V. M. Oliveira, N. M. Khalil, E. Carraro
doaj   +1 more source