Results 11 to 20 of about 13,097,347 (378)
Amphotericin-B/amphotericin-B-liposomal [PDF]
Reactions Weekly, 2022 semanticscholar +2 more sources
bioRxiv, 2021 Candida auris has emerged as a healthcare-associated and multidrug-resistant fungal pathogen of great clinical concern. While as much as 50% of C. auris clinical isolates are reported to be resistant to amphotericin B, to date, no mechanisms contributing
J. Rybak +10 more
semanticscholar +1 more source
Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study [PDF]
, 2016 The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between ...
Bonev, Boyan B. +5 more
core +7 more sources
Liposomal amphotericin B—the past [PDF]
Journal of Antimicrobial Chemotherapy, 2022 Abstract The discovery of amphotericin B, a polyene antifungal compound, in the 1950s, and the formulation of this compound in a liposomal drug delivery system, has resulted in decades of use in systemic fungal infections. The use of liposomal amphotericin B formulation is referenced in many international guidelines for the treatment of ...
R J Brüggemann +2 more
openaire +3 more sources
Frontiers in Genetics, 2023 Aspergillus fumigatus is one of the most common pathogenic fungi, which results in high morbidity and mortality in immunocompromised patients. Amphotericin B (AMB) is used as the core drug for the treatment of triazole-resistant A. fumigatus.
Meng-Meng Chen +7 more
doaj +1 more source
Pharmacodynamics of Amphotericin B Deoxycholate, Amphotericin B Lipid Complex, and Liposomal Amphotericin B against Aspergillus fumigatus [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT Amphotericin B is a first-line agent for the treatment of invasive aspergillosis. However, relatively little is known about the pharmacodynamics of amphotericin B for invasive pulmonary aspergillosis. We studied the pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAMB), amphotericin B ...
Z. Al-Nakeeb +5 more
semanticscholar +3 more sources
Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. [PDF]
PLoS ONE, 2014 The polyene antifungal agent Amphotericin B exhibits potent and broad spectrum fungicidal activity. However, high nephrotoxicity can hinder its administration in resource poor settings.
Dithi Banerjee +2 more
doaj +1 more source
Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy
Pharmaceutics, 2020 Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis.
C. Faustino, L. Pinheiro
semanticscholar +1 more source
Single dose pharmacodynamics of amphotericin B against Aspergillus species in an in vitro pharmacokinetic/pharmacodynamic model [PDF]
, 2013 Conventional MIC testing of amphotericin B results in narrow MIC ranges challenging the detection of resistant strains. In order to discern amphotericin B pharmacodynamics, the in vitro activity of amphotericin B was studied against Aspergillus isolates ...
Al-Saigh, Rafal +5 more
core +1 more source