Results 21 to 30 of about 13,189,470 (203)

Liposomal amphotericin B—the future [PDF]

Journal of Antimicrobial Chemotherapy, 2022
AbstractAdvances in medicine have led to a growing number of people with compromised or suppressed immune systems who are susceptible to invasive fungal infections. In particular, severe fungal infections are becoming increasingly common in ICUs, affecting people within and outside of traditional risk groups alike.
M Hoenigl, R Lewis, F L van de Veerdonk, P E Verweij, O A Cornely   +4 more
openaire   +6 more sources

Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model [PDF]

, 2011
In conventional MIC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations.
Thomas J. Walsh, Emmanuel Roilides, Aristea Velegraki, Walsh, Thomas, Zerva, Loukia, Meletiadis, Joseph, Joseph Meletiadis, Roilides, Emmanuel, Rafal Al-Saigh, Velegraki, Aristea, Loukia Zerva, Al Saigh, Rafal   +11 more
core   +1 more source

Amphotericin B nasal spray has no effect on nasal polyps [PDF]

, 2006
Nasal polyps and chronic rhinosinusitis are the products of an inflammatory process. Recently, fungal involvement has been thought to stimulate the development of polyps, and administration of antifungal agents was therefore considered a potential ...
Caversaccio, M, Hänni, C, Baumann, A, Helbling, A, Baumann A, Hänni C, Helbling A, Caversaccio M   +7 more
core   +2 more sources

Do Ophthalmic Solutions of Amphotericin B Solubilised in 2-Hydroxypropyl-γ-Cyclodextrins Possess an Extended Physicochemical Stability?

Pharmaceutics, 2020
Fungal keratitis is a sight-threatening disease for which amphotericin B eye drops is one of the front-line treatments. Unfortunately, there are currently no commercial forms available, and there is little data concerning the long-term stability of ...
Philip Chennell, Mouloud Yessaad, Florence Abd El Kader, Mireille Jouannet, Mathieu Wasiak, Yassine Bouattour, Valérie Sautou   +6 more
doaj   +1 more source

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, T. S. Harrison, J. Day, Loyse, A   +9 more
core   +1 more source

Antileishmanial activity of nano-amphotericin B deoxycholate [PDF]

, 2008
Objectives The aim of the present study was to compare the efficacy of a nano form of amphotericin B deoxycholate with that of conventional amphotericin B deoxycholate for the treatment of visceral leishmaniasis. Methods We have formulated nanoparticles
Rai, Madhukar, T. P. Yadav, Kumar, Subodh, M. Rai, Dube, Anuradha, Yadav, Thakur Prasad, A. Dube, Prajapati, Vijay Kumar, K. D. Manandhar, V. K. Prajapati, Manandhar, Krishna Das, Sundar, Shyam, O. N. Srivastava, Srivastava, Onkar Nath, S. Kumar, S. Sundar   +15 more
core   +1 more source

Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis: In vitro and in vivo study

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in mice. Methods: GC/MS was used for analysis of active constituents
Enas M Ali, Manal A Alfwuaires, Gehan M Badr   +2 more
doaj   +1 more source

Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).

, 2013
A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20-50%.
Croft, Simon L, Mohamed-Ahmed, Abeer HA, Simon L. Croft, Les, Karolina A, Karin Seifert, Seifert, Karin, Brocchini, Stephen, Stephen Brocchini, Abeer H. A. Mohamed-Ahmed, Karolina A. Les, Brocchini, S., Mohamed-Ahmed, A.H.A., Les, K.A., Seifert, K., Croft, S.L.   +14 more
core   +1 more source

Atrioventricular block related to liposomal amphotericin B [PDF]

, 2014
Atrioventricular block can occur in normal children, young adults or athletes. It is also associated with underlying heart disease or occurs as a drug adverse effect. Amphotericin B is used in the treatment of invasive fungal infections. Cardiac toxicity
Rebelo, M, Almeida, H, Nunes, P, Sanches, B   +3 more
core   +2 more sources

Efficacy of combination therapy of amphotericin and posaconazole in treatment of mucormycosis

Journal of Applied Pharmaceutical Research, 2023
Background: Mucormycosis is an opportunistic systemic fungal infection which is debilitating caused by order Mucorales. The standard management of mucormycosis consists of aggressive debridement of the infected tissue and parenteral anti-fungal therapy ...
Sridhara S, Ramesh Sanappa, Nandini P, Gayatri Jayan, Gangadhara KS   +4 more
doaj   +1 more source