Results 21 to 30 of about 91,427 (251)

Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study

Precision Medication
Background: Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy.
Shuai Liu, Shizhao Yuan, Yan Liu, Shuoxian Jia, Yan Zhao, Ziyi Wang, Chunhua Zhou, Jing Yu   +7 more
doaj   +1 more source

Taming Amphotericin B [PDF]

Bioconjugate Chemistry, 2015
A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine
Vaclav, Janout, Wiley A, Schell, Damien, Thévenin, Yuming, Yu, John R, Perfect, Steven L, Regen   +5 more
openaire   +2 more sources

Effects of Several Common Antifungal Drugs (Clotrimazole, Miconazole, Fluconazole) alone and in Combination with Amphotericin B on Candida Species Isolated from Chronic Candidal Vulvovaginitis [PDF]

Journal of Advanced Biomedical Sciences, 2014
Background; Objective: Candidal vulvovaginitis occurs in female genital by the over growth of candida especially candida albicans. This infection may be resistant to therapy and occasionally becomes chronic.
Efate alsadat shojaei, Mehraban Falahati, Faride zaini, Parivash kord bache, Parvaneh rahimi moghadam, Mohammad reza aghamirian, Shima Nozari, Ayesheh Makhdoomi, Sekhavatv ameri, Sanam afshar moghadam   +9 more
doaj   +2 more sources

Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2017
Objective: Amphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal ...
Do-Yeon Cho, Kyle J. Hoffman, Gobind S. Gill, Dong-Jin Lim, Daniel Skinner, Calvin Mackey, Steven M. Rowe, Bradford A. Woodworth   +7 more
doaj   +1 more source

Efficacy of Systemic Treatment for Leishmania tropica Cutaneous Leishmaniasis

Acta Dermato-Venereologica, 2022
The effectiveness of systemic treatment for Leishmania tropica cutaneous leishmaniasis remains unclear. The purpose of the study is to evaluate the efficacy and safety of systemic treatments for L. tropica cutaneous leishmaniasis.
Michal Solomon, Shoshana Greenberger, Maya Milner, Felix Pavlotzky, Aviv Barzilai, Eli Schwartz, Noa Hadayer, Sharon Baum   +7 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Using single-dose liposomal amphotericin B for cryptococcal meningitis induction therapy: nurse pearls and practical perspectives [version 2; peer review: 2 approved]

Wellcome Open Research
Background In Uganda where the burden of HIV-associated cryptococcal meningitis is high, conventional amphotericin B deoxycholate has been standard to manage patients with cryptococcal meningitis in research settings.
Richard Kwizera, Cynthia Ahimbisibwe, Jane Frances Ndyetukira, David B. Meya, Carol Namujju   +4 more
doaj   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

Advanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn, Hyeonji Kim, Nam Than, Juhyeok Kim, Jangwon Yoon, Dohui Kim, Hyun Jung Kim, Dong Sung Kim   +7 more
wiley   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source